Prognostic Models for HCC Based on Tumor Micronecrosis

NCT ID: NCT05837065

Last Updated: 2023-05-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

765 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-09-15

Study Completion Date

2023-12-30

Brief Summary

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The heterogeneity of hepatocellular carcinoma (HCC) leads to the unsatisfying predicting performance of current staging systems. HCC patients with pathological tumor micronecrosis have immunosuppressive microenvironment. We aimed to develop novel prognostic models by integrating micronecrosis to more precisely predict the survival of HCC patients after hepatectomy.

Detailed Description

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Conditions

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Hepatocellular Carcinoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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training cohort

HCC patients receiving curative hepatic resection

observing whether HCC patients having tumor micronecrosis

Intervention Type OTHER

whether HCC patients having tumor micronecrosis or not

validation cohort

HCC patients receiving curative hepatic resection

observing whether HCC patients having tumor micronecrosis

Intervention Type OTHER

whether HCC patients having tumor micronecrosis or not

Interventions

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observing whether HCC patients having tumor micronecrosis

whether HCC patients having tumor micronecrosis or not

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. pathologically diagnosed as HCC;
2. curative hepatectomy with R0 resection;
3. conserved liver function with Child Pugh class A or B

Exclusion Criteria

1. with macrovascular invasion or extrahepatic metastasis;
2. receiving other anti-tumor treatments such as TACE or systemic drugs;
3. with other primary cancers;
4. incomplete follow-up data;
5. without sufficient formalin-fixed, paraffin-embedded (FFPE) specimens for micronecrosis evaluation
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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TingBo Liang

Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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the First Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Tingbo Liang, PhD

Role: CONTACT

Qi Zhang, MD

Role: CONTACT

13819137113

Facility Contacts

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Tingbo Liang, MD, PHD

Role: primary

086-571-87236688

Other Identifiers

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PMforHCC

Identifier Type: -

Identifier Source: org_study_id

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