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Prognostic Impact of Anatomical Resection Vs. Non-anatomical Resection for HCC

NCT ID: NCT01236989

Last Updated: 2010-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2017-12-31

Brief Summary

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Prognostic impact of AR vs NAR

Detailed Description

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Whether anatomical is better than non anatomical resection for HCC is still debated. This prospective randomized study aimed to address which approach is better in terms of patients prognosis.

Conditions

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Patients Affected by Hepatocellular Carcinoma Disease-Free Survival Overall Survival

Keywords

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anatomical resection non-anatomical resection IOUS-guided finger compression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Anatomical resection

Group Type EXPERIMENTAL

anatomical liver resection

Intervention Type PROCEDURE

anatomical liver resection by means of IOUS-finger compression

Non-anatomical resection

Group Type ACTIVE_COMPARATOR

Non-anatomical liver resection

Intervention Type PROCEDURE

non-anatomical liver resection

Interventions

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anatomical liver resection

anatomical liver resection by means of IOUS-finger compression

Intervention Type PROCEDURE

Non-anatomical liver resection

non-anatomical liver resection

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patient affected by single HCC
* patients in whom liver resection is indicated
* HCC without vascular invasion and/or thrombosis

Exclusion Criteria

* multinodular HCC
* metastatic disease
* spontaneous tumor rupture
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Milan

OTHER

Sponsor Role lead

Responsible Party

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Liver Surgery Unit, 3rd Department of Surgery, University of Milan School of Medicine, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy

Principal Investigators

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Guido Torzilli, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

IRCCS Istituto Clinico Humanitas, Milan, Italy

Locations

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IRCCS Istituto Clinico Humanitas

Rozzano, Milan, Italy

Site Status

Countries

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Italy

Central Contacts

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Guido Torzilli, MD, PhD

Role: CONTACT

Phone: +39 02 8224

Email: [email protected]

Facility Contacts

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Guido Torzilli, MD, PhD

Role: primary

References

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Hasegawa K, Kokudo N, Imamura H, Matsuyama Y, Aoki T, Minagawa M, Sano K, Sugawara Y, Takayama T, Makuuchi M. Prognostic impact of anatomic resection for hepatocellular carcinoma. Ann Surg. 2005 Aug;242(2):252-9. doi: 10.1097/01.sla.0000171307.37401.db.

Reference Type BACKGROUND
PMID: 16041216 (View on PubMed)

Torzilli G, Procopio F, Cimino M, Del Fabbro D, Palmisano A, Donadon M, Montorsi M. Anatomical segmental and subsegmental resection of the liver for hepatocellular carcinoma: a new approach by means of ultrasound-guided vessel compression. Ann Surg. 2010 Feb;251(2):229-35. doi: 10.1097/SLA.0b013e3181b7fdcd.

Reference Type BACKGROUND
PMID: 19838106 (View on PubMed)

Torzilli G, Makuuchi M. Ultrasound-guided finger compression in liver subsegmentectomy for hepatocellular carcinoma. Surg Endosc. 2004 Jan;18(1):136-9. doi: 10.1007/s00464-003-9024-x. Epub 2003 Nov 21.

Reference Type BACKGROUND
PMID: 14625736 (View on PubMed)

Other Identifiers

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AR vs NAR

Identifier Type: -

Identifier Source: org_study_id