Effects of Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety in Elderly Patients
NCT ID: NCT06307717
Last Updated: 2024-04-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
8000 participants
OBSERVATIONAL
2020-04-01
2022-04-30
Brief Summary
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Detailed Description
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This study retrospectively analysed data from a prospective database of patients aged 65 and above who underwent non-cardiac, non-neurosurgical elective surgery in 18 tertiary hospitals across 10 provinces in China. Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic. Binary logistic regression analyses were conducted, and propensity score-matching (PSM) and subgroup analyses were also applied.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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volatile anaesthetic (sevoflurane, isoflurane, desflurane）
Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.
volatile anaesthetic (sevoflurane, isoflurane, desflurane)
Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.
control
Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.
No interventions assigned to this group
Interventions
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volatile anaesthetic (sevoflurane, isoflurane, desflurane)
Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2. ASA classification of Ⅳ or above
3. history of serious mental illness or long-term use of psychotropic drugs
4. patients either died or were transferred to the intensive care unit within 7 days of the surgery
5. subjects with missing covariate data
65 Years
ALL
No
Sponsors
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Beijing Tsinghua Changgeng Hospital
OTHER
Peking University First Hospital
OTHER
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
OTHER
Xiangya Hospital of Central South University
OTHER
Beijing Anzhen Hospital
OTHER
Central South University
OTHER
Peking University People's Hospital
OTHER
Zhejiang University
OTHER
Fudan University
OTHER
Sun Yat-sen University
OTHER
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
OTHER
China-Japan Friendship Hospital
OTHER
The Affiliated Hospital Of Guizhou Medical University
OTHER
First Affiliated Hospital of Xinjiang Medical University
OTHER
First Affiliated Hospital of Guangxi Medical University
OTHER
Taihe Hospital
OTHER
Chinese PLA General Hospital
OTHER
Responsible Party
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Weidong Mi
Director (Cheif expert of National key research and development program of China 2018YFC2001900)
Principal Investigators
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WEIDONG MI, PhD
Role: STUDY_CHAIR
Chinese PLA General Hospital
Locations
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Chinese PLA General Hospital
Beijing, Beijing Municipality, China
Countries
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Other Identifiers
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PLAGH-DA-002
Identifier Type: -
Identifier Source: org_study_id
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