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Effects of Propofol and Sevoflurane on Early POCD in Elderly Patients With Metabolic Syndrome

NCT ID: NCT02766062

Last Updated: 2016-06-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

94 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-09-30

Study Completion Date

2016-05-31

Brief Summary

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The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Detailed Description

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By now, a series risk factors of cardiovascular diseases, which are also related to the development of postoperative cognitive dysfunction (POCD), are becoming more common.The investigators don't know whether propofol based anesthesia has a more severe impact on early postoperative cognitive function than sevoflurane in elderly patients with metabolic syndrome. In this study, the investigators want to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Conditions

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Postoperative Complications

Keywords

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Postoperative cognitive dysfunction metabolic syndrome propofol sevoflurane

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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propofol group

Patients with metabolic syndrome were randomly assigned to receive propofol anesthesia

Group Type ACTIVE_COMPARATOR

metabolic syndrome

Intervention Type OTHER

metabolic syndrome

sevoflurane group

Patients with metabolic syndrome were randomly assigned to receive sevoflurane anesthesia

Group Type ACTIVE_COMPARATOR

metabolic syndrome

Intervention Type OTHER

metabolic syndrome

Interventions

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metabolic syndrome

metabolic syndrome

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* aged ≥60 years;
* ASAⅡor Ⅲ
* noncardiac surgery and nonneural surgery

Exclusion Criteria

* Mini Mental State Examination \[MMSE\] score too low
* chronic alcoho and drug abuse
* disturbed renal and liver function
* history of a cerebrovascular accident
* permanent ventricular pacing
* preoperative cognitive deficits
* lack of cooperation
Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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General Hospital of Ningxia Medical University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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NZ1651

Identifier Type: -

Identifier Source: org_study_id