Hard and Soft Tissue Dimensional Change After Consecutive Extractions and Unassisted Socket Healing in the Esthetic Zone

NCT ID: NCT06261762

Last Updated: 2024-02-15

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-02-29
• Study Completion Date: 2026-06-30

Brief Summary

The goal of this observational study is to evaluate the post-extraction hard and soft tissue dimension changes in patients requiring consecutive extractions and unassisted socket healing in the anterior maxilla. The main questions it aims to answer are:

• Is significant alveolar ridge resorption observed at center sites after consecutive extractions
• Is significant alveolar ridge resorption observed at the interalveolar septum after consecutive extractions, are different extraction sites associated with significantly different bone resorption
• Is a thick or thin wall phenotype associated with the amount of bone resorption
• Is soft tissue thickness change associated with the corresponding location (extraction site or interalveolar septum) and post-extraction thickness of the bone
• Is the interdental papilla height significantly affected after extractions.

Participants will undergo consecutive (two) extractions and will be evaluated after subsequent unassisted socket healing for 8 weeks.

Conditions

Wound Heal

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• 18+ years old
• Require consecutive (two) teeth replacement in the anterior maxilla
• Signed informed consent
• No significant medical conditions
• Patients with healthy periodontal conditions or previously treated to controlled and stable conditions

Exclusion Criteria

• General medical (American Society of Anesthesiologists, ASA, class III or IV) and/or psychiatric contraindications
• Pregnancy or nursing
• Any interfering medication such as steroid therapy or bisphosphonate therapy
• Uncontrolled diabetes
• Autoimmune diseases or inflammatory diseases affecting the intraoral tissues
• Radiation therapy to head or neck region

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Feng Wang

Role: PRINCIPAL_INVESTIGATOR

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Central Contacts

Xinbo Yu

Role: CONTACT

xinboyu@proton.me

18019409340

Other Identifiers

SDC-24-1

Identifier Type: -

Identifier Source: org_study_id