Effect of Platelet-rich Fibrin on Soft Tissue, Periodontal Pocket Healing and Alveolar Bone Height After Third Molar Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-12-01

Study Completion Date

2021-12-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

A Randomized, controlled clinical trial and split-mouth design was performed to assess and compare the effect of platelet-rich fibrin (PRF) on soft tissue healing, periodontal pocket depth and alveolar bone height distal to second molar of the study and control groups after third molar surgical removal.

Sample include of participants who had indication of impacted lower third molars extraction on both sides with symmetrically orientation and same difficult index. All participants had same extraction protocol on both side at Department of Oral surgery, Faculty of Odonto-stomatology, University of Medicine and Pharmacy, Ho Chi Minh City.

Soft tissue healing, periodontal pocket depth and distal bone height were evaluation by an independent investigator.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effectiveness of Platelet Rich Plasma in Wound Healing

NCT02831374

Impacted Third Molar Tooth

COMPLETED EARLY_PHASE1

Effect of Injectable Platelet Rich Fibrin (i-PRF) on Extraction Socket Healing: A Split-Mouth Randomized Study.

NCT07257328

Wound Healing Tooth Extraction Site Healing

COMPLETED NA

Comparison of the Effect of A-PRF and L-PRF on Outcomes After Removal of Impacted Mandibular Third Molar

NCT03672669

Pain, Postoperative Trismus Swelling

COMPLETED NA

Prevention of Mandibular Third Molar Extraction- Associated Periodontal Defects Using Platelet-Rich Fibrin

NCT04033744

Periodontal; Lesion Periodontal Pocket Molar, Third

COMPLETED NA

Healing of Mandibular Third Molar Extraction Sockets Using Platelet Concentrates and Photobiomodulation

NCT07324213

Impacted Mandibular Third Molar Alveolar Bone Loss Impacted Mandibular Third Molar Extraction

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Platelet-rich Fibrin

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

split-mouth study, 1 side would be the study side and other side would be control side

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

control

standard third molar surgery following surgical protocol of Department of Oral Surgery, University of Medicine and Pharmacy

Group Type ACTIVE_COMPARATOR

standard third molar surgical removal

Intervention Type OTHER

standard third molar surgery following surgical protocol of Department of Oral Surgery, University of Medicine and Pharmacy

PRF

PRF was applied in third molar socket after removal following surgical protocol of Department of Oral Surgery, University of Medicine and Pharmacy

Group Type EXPERIMENTAL

PRF

Intervention Type OTHER

centrifuge patient's blood to collect 1 block of yellowish condensed fibrin, which is platelet-rich fibrin

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

PRF

centrifuge patient's blood to collect 1 block of yellowish condensed fibrin, which is platelet-rich fibrin

Intervention Type OTHER

standard third molar surgical removal

standard third molar surgery following surgical protocol of Department of Oral Surgery, University of Medicine and Pharmacy

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patient over 18 years old.
* Good general health.
* Bilateral lower third molars equivalent in inclination and Pell and Gregory's impaction classification (classification II, III and B, C). The assessment of equivalence between two mandibular third molars was determined on the panoramic radiograph.
* The difference of third molar inclination on both sides not greater than 15 degrees.
* The patient consented to participate in the study after hearing clearly the explanation of purposes and requirements of the study.

Exclusion Criteria

* Patients with any systemic disease contraindicated for surgery.
* Presence of acute inflammation or infection at third molar areas.
* Patients refused to participate in the study, did not comply with treatment or did not come to the follow-up examination as required.
* The difference in surgical time between the two groups was more than 10 minutes.

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes