Role of PCO2 Gap as Predictor of Clinical Outcome in ICU Septic Patients

NCT ID: NCT06256198

Last Updated: 2024-02-13

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-02-29
• Study Completion Date: 2024-06-30

Brief Summary

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, if not recognized early and managed promptly, it can lead to septic shock, multiple organ failure and death. Sepsis is associated with high mortality, and the early recognition of the signs of tissue hypo perfusion is crucial in its management.

This prospective study was aimed to detect that PCO2 gap can be taken as a reliable prognostic tool in septic patients

Detailed Description

In the community setting, sepsis often presents as the clinical deterioration of common and preventable infections. Sepsis also frequently results from infections acquired in health care settings, which are one of the most frequent adverse events during care delivery and affect hundreds of millions of patients worldwide every year The venous-to-arterial carbon dioxide difference (Pv-aCO2) can indicate the adequacy of microvascular blood flow in the early phases of resuscitation in sepsis. Hence, other resuscitation goals, such as PCO2 gap, have been suggested, due to their ability to predict adverse clinical outcomes and simplicity in patients achieving normal oxygen-derived parameters during the early phases of resuscitation in septic shock.

Blood lactate level is also useful in evaluating sepsis. Serum lactate is a good indicator of the presence of hypoxic tissue during septic shock, since its production takes place during Anerobic metabolism.

Procalcitonin (PCT) is the precursor of calcitonin, and higher levels are associated with the development of sepsis. Com¬monly, there is an elevation of PCT levels 4 h after the on¬set of symptoms, peaking between 8 h and 24 h.

Conditions

Sepsis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Group S

survivors

measurement of serum lactate and procalcitonin and PCO2 gap

Intervention Type: OTHER

measurement of serum lactate, procalcitonin and PCO2 gap

Group M

non survivors

measurement of serum lactate and procalcitonin and PCO2 gap

Intervention Type: OTHER

measurement of serum lactate, procalcitonin and PCO2 gap

Interventions

measurement of serum lactate and procalcitonin and PCO2 gap

measurement of serum lactate, procalcitonin and PCO2 gap

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Adult septic patients ≥ 21 years old

Exclusion Criteria

• Patients with history of chronic obstructive pulmonary disease and bronchial asthma.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ain Shams University

OTHER

Sponsor Role: lead

Responsible Party

Ahmed wagih Ezzat deusouky

lecturer of anesthesia

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Ahmed El-Dolah, lecturer of Anesthesia

Role: CONTACT

a_wagih82@yahoo.com

+20111113077

Other Identifiers

MS 719/2022

Identifier Type: -

Identifier Source: org_study_id