Defining Volume Status in Sepsis With Extracellular Water Measurement

NCT ID: NCT06512129

Last Updated: 2026-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-01

Study Completion Date

2027-12-01

Brief Summary

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The goal of this observational study is to learn about the influence of extracellular water on volume status in adult sepsis patients presenting with hemodynamic instability. The main question it aims to answer is:

• Can measurement of extracellular water (MoistureMeterD, Delfin Technologies Ltd, Kuopio, Finland) contribute to the description of hemodynamic instability in adult sepsis patients.

Patients with sepsis admitted to intensive care will receive standard care with the addition of measurement of extracellular water.

Detailed Description

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Adult patients with sepsis admitted to any of our ICUs will be recruited. During the first three days after inclusion blood samples and extended non-invasive monitoring, including monitoring of the microcirculation (CytoCam) and measurement of extracellular water (dielectronic constant), will be added to routine care and monitoring.

Conditions

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Sepsis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Adults with sepsis.

Exclusion Criteria

* Pregnancy, other than sepsis known cause of shock.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Uppsala University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Annelie Barrueta Tenhunen, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Uppsala University, Region Uppsala

Locations

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AnOpIva

Uppsala, Uppsa, Sweden

Site Status RECRUITING

Countries

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Sweden

Central Contacts

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Annelie Barrueta Tenhunen, MD, PhD

Role: CONTACT

+46728881882

Facility Contacts

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Annelie B Tenhunen

Role: primary

+4618660000

References

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Nuutinen J, Ikaheimo R, Lahtinen T. Validation of a new dielectric device to assess changes of tissue water in skin and subcutaneous fat. Physiol Meas. 2004 Apr;25(2):447-54. doi: 10.1088/0967-3334/25/2/004.

Reference Type BACKGROUND
PMID: 15132310 (View on PubMed)

Toro C, Markarian B, Mayrovitz HN. Breast Cancer-Related Lymphedema Assessed via Tissue Dielectric Constant Measurements. Cureus. 2024 Apr 29;16(4):e59261. doi: 10.7759/cureus.59261. eCollection 2024 Apr.

Reference Type BACKGROUND
PMID: 38813316 (View on PubMed)

De Backer D, Cecconi M, Chew MS, Hajjar L, Monnet X, Ospina-Tascon GA, Ostermann M, Pinsky MR, Vincent JL. A plea for personalization of the hemodynamic management of septic shock. Crit Care. 2022 Dec 1;26(1):372. doi: 10.1186/s13054-022-04255-y.

Reference Type BACKGROUND
PMID: 36457089 (View on PubMed)

Other Identifiers

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2023-06866-01.1

Identifier Type: -

Identifier Source: org_study_id

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