Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
68 participants
INTERVENTIONAL
2024-03-01
2028-02-29
Brief Summary
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Aim: This work aims to investigate individual differences in glucose metabolism and directional connectivity regulating the neuronal stress response.
Design: 68 healthy volunteers will undergo two simultaneous PET/MRI measurements one week apart. Participants will complete the Montreal Imaging Stress Test during each measurement and in-between. Effects of stress on cognitive performance will be assessed using the n-back working memory task. Individual cortisol levels will be acquired to identify stress (non)responders as well as (non)habituators.
Implications: This work will characterize differences between stress responders vs. non-responders and stress habituators vs. non-habituators in terms of energy metabolism and network connectivity. This individual difference in the stress response may represent an important cornerstone for future evaluation of patients with mental disorders.
Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Stress
Montreal Imaging Stress Test during each PET/MRI measurement and in-between
Montreal Imaging Stress Test
In the Montreal Imaging Stress Test, participants are required to solve basic mathematical tasks, but the allowed reaction time is set lower than their average.
Interventions
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Montreal Imaging Stress Test
In the Montreal Imaging Stress Test, participants are required to solve basic mathematical tasks, but the allowed reaction time is set lower than their average.
Eligibility Criteria
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Inclusion Criteria
* right-handedness
* willingness and competence to sign the informed consent form
Exclusion Criteria
* History of or current substance abuse or medication, including antipsychotic, antidepressant and antianxiety agents
* Pregnancy of current breast-feeding
* Contraindications for MRI-scanning (e.g., metal implants, steel grafts, etc.), including dental implants causing signal artifacts
* For subjects participating in earlier studies using ionizing radiation, the total radiation exposure of 30 mSv over the last 10 years must not be exceeded, as specified in the Austrian legislation on radiation protection Accordingly, body weight \> 105 kg is an exclusion criterion.
* Failure to comply with the study protocol or to follow the instructions of the investigating team.
18 Years
40 Years
ALL
Yes
Sponsors
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University of Konstanz
OTHER
Rupert Lanzenberger
OTHER
Responsible Party
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Rupert Lanzenberger
Prof. PD MD, Head Neuroimaging Labs
Principal Investigators
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Andreas Hahn, Assoc.Prof.
Role: PRINCIPAL_INVESTIGATOR
Department of Psychiatry and Psychtherapy, Medical University of Vienna
Locations
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Department of Psychiatry and Psychotherapy, Medical University of Vienna
Vienna, , Austria
Countries
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Central Contacts
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Facility Contacts
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Rupert Lanzenberger, Prof
Role: primary
Related Links
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Neuroimaging Labs, Dept. of Psychiatry and Psychotherapy, Medical University of Vienna
Other Identifiers
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PSY-NIL-0012
Identifier Type: -
Identifier Source: org_study_id