Speech Pattern Evaluation and Analysis for Knowledge of AD

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-01-22

Study Completion Date

2029-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of this observational study is to validate changes in speech as a measure of cognition in individuals at increased risk of Alzheimer's disease and related dementias (ADRD). This study aims to clarify how speech may be affected by Alzheimer's disease.

Participants will complete speech collection sessions and a survey at home using an iPad. Participants can expect to be in the study for 3 years.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Language, Speech and Motor Function in MCI Due to AD and Alzheimer's Disease

NCT06508268

Alzheimer's Disease MCI Due to AD Dementia Alzheimers

RECRUITING

Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients

NCT07200739

Dementia (Diagnosis) Alzheimer Dementia (AD) Vascular Dementia (VaD) +4 more

ENROLLING_BY_INVITATION

Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping

NCT04928976

Alzheimer Disease Preclinical Alzheimer's Disease Prodromal Alzheimer's Disease +2 more

COMPLETED

Preventing Alzheimer's With Cognitive Training

NCT03848312

RECRUITING PHASE3

Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech - PAST Extension

NCT04851496

Alzheimer Disease Preclinical Alzheimer's Disease Prodromal Alzheimer's Disease +2 more

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Digital technology, including recorded speech, has the capability of providing a wealth of information about early changes to cognition and communication associated with developing Alzheimer's disease pathology, with the potential for highly accessible, yet low-burden measurement. In this project, researchers will recruit a subset of participants from two longitudinal, observational cohort studies enriched for individuals at risk for or living with Alzheimer's disease to record their speech at home with a mobile device, longitudinally. Our interdisciplinary team will then validate digital markers across all stages of Alzheimer's Disease and Related Dementias (ADRD), including the prodromal phase, and can enhance sensitivity and specificity of speech metrics while contributing valuable information about remote, noninvasive, and accessible assessment and disease monitoring.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Wisconsin Alzheimer's Disease Research Center Wisconsin Registry for Alzheimer's Prevention

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

TalkTracker

Participants will be asked to complete the speech collection procedures remotely/at home once per week for 8 weeks. The 8-week period of weekly remote speech collection will take place yearly for a total of 3 years. At the end of each 8-week study period for years 1-3, participants will complete a survey that asks questions about how easy/difficult the application was to use, how frustrated they felt using the application, and other usability questions.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Must be enrolled in the Wisconsin Alzheimer's Disease Research Center (W-ADRC) Clinical Core or IMPACT studies, or in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
* Cognitively unimpaired or have a diagnosis of Mild Cognitive Impairment (MCI)
* Ages 40-80 years
* Completion of a W-ADRC or WRAP study visit within the past or upcoming 12 months
* Have provided W-ADRC or WRAP with blood plasma Alzheimer's Disease

Exclusion Criteria

* Not actively enrolled in W-ADRC or WRAP
* Diagnosis of dementia
* Impaired capacity or unwilling to consent
* Major neurological conditions
* Speech disorders

Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes