Early Detection of Alzheimer's Disease and Affective Disorders by Automated Voice and Speech Analysis (PLATA)
NCT ID: NCT05943834
Last Updated: 2024-09-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
100 participants
OBSERVATIONAL
2023-07-13
2025-10-10
Brief Summary
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Using data collected as part of routine care, speech patterns will be compared to known biomarkers of Alzheimer's disease, such as amyloid 1-42 and p-Tau in CSF (cerebrospinal fluid).
If biomarkers of speech can be identified in Alzheimer's disease, it is possible that patients and research participants will no longer need to undergo need to undergo the intensive and invasive baseline biomarker methods currently used, such as lumbar punctures and PET scans.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients with a minor or major neurocognitive disorder
Every patient will receive one semi-automated phone call, during the call a series of cognitive tasks will be performed.
Each task will be recorded in a secondary audio stream which records the participant responses to allow for deep speech analysis of performance on these tasks
Series of cognitive tasks during a semi-automated call
Tasks:
* Verbal learning recall (immediate) or Story Recall task (immediate)
* Narrative Storytelling /free speech
* Verbal fluency task
* Verbal learning recall (delayed) or Story Recall task (delayed)
Interventions
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Series of cognitive tasks during a semi-automated call
Tasks:
* Verbal learning recall (immediate) or Story Recall task (immediate)
* Narrative Storytelling /free speech
* Verbal fluency task
* Verbal learning recall (delayed) or Story Recall task (delayed)
Eligibility Criteria
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Inclusion Criteria
* Diagnosis relevant biomarker and neuropsychological data already available
* Cognitively healthy to very mild dementia (CDR score max. 0.5)
* Sufficient knowledge of the study language to understand study information, non opposition form,and questionnaires
* Expression of non opposition
Exclusion Criteria
* Patient protected by law, under guardianship or curator ship, or not able to participate in a clinical study according to the article L.1121-16 of the French Public Health Code
50 Years
100 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de Nice
OTHER
Responsible Party
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Principal Investigators
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Eric ETTORE, MD
Role: PRINCIPAL_INVESTIGATOR
Centre Hospitalier Universitaire de Nice
Locations
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CHU de Nice
Nice, , France
Countries
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Central Contacts
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Facility Contacts
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Lemaire Justine
Role: primary
Foussat Valérie
Role: backup
Other Identifiers
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23-PP-03
Identifier Type: -
Identifier Source: org_study_id
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