Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
186 participants
OBSERVATIONAL
2022-04-01
2024-02-01
Brief Summary
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* Does the prevalence of NSS significantly differ among patients with neurodegenerative dementias compared to controls?
* Are NSS associated with neuropsychiatric alterations in dementia patients?
* Do NSS correlate with cognitive screening tools?
* Do NSS increase over time in patients with neurodegenerative dementias?
Participants will undergo assessments including:
* Evaluation of NSS using the Heidelberg scale
* Neuropsychiatric assessments
* Cognitive screening using the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB)
Researchers will compare dementia groups (Alzheimer's disease, Frontotemporal dementia, Corticobasal syndrome and Lewy body dementia) to controls to determine differences in NSS prevalence. Additionally, associations between NSS and neuropsychiatric symptoms, as well as cognitive performance, will be explored.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Neurodegenerative dementias
Subjects with either Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies or corticobasal syndrome
Neurological Soft Signs
Neurological Soft Signs score according to the Heidelberg Manual
Control
Subjects without dementia
Neurological Soft Signs
Neurological Soft Signs score according to the Heidelberg Manual
Interventions
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Neurological Soft Signs
Neurological Soft Signs score according to the Heidelberg Manual
Eligibility Criteria
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Inclusion Criteria
* MMSE score greater than 10.
* Age and gender-matched controls without a history of neurological or psychiatric conditions.
Exclusion Criteria
* History of neurological or psychiatric conditions predating the dementia diagnosis.
* Substance or alcohol abuse history.
* Known comorbidities affecting neurological or psychiatric function.
* MMSE score less than or equal to 10.
* Inability to provide informed consent.
18 Years
ALL
Yes
Sponsors
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University of Milano Bicocca
OTHER
Responsible Party
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Principal Investigators
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Lucio Tremolizzo, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Milano Bicocca
Locations
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Fondazione IRCCS San Gerardo dei Tintori
Monza, Lombardy, Italy
Countries
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Other Identifiers
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DemeNSS (3785)
Identifier Type: -
Identifier Source: org_study_id
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