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Social Cognition and Personality Changes in Alzheimer's & Parkinson's Disease & Frontotemporal Lobar Degeneration

NCT ID: NCT02964611

Last Updated: 2024-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-01-31

Study Completion Date

2016-08-16

Brief Summary

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The aim of this study is to compare personality and social cognition changes, including emotion detection and self-awareness, and neuroanatomical correlates in patients, and how that affects the caregiver-patient relationship.

Detailed Description

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The purpose of this study is to understand social cognition changes in patients with Alzheimer's disease (AD), Parkinson's disease (PD), and Frontotemporal Lobar Degeneration (FTLD), which includes Progressive Supranuclear Palsy (PSP), Corticobasal Syndrome (CBS) and Frontotemporal Dementia (FTD - behavioural variant frontotemporal dementia, progressive non-fluent aphasia and semantic dementia), and the effect of these changes on the patients' relationship with their caregivers. In addition, the study aims to provide a greater clarity in the neuroanatomical correlates of social cognition in patients with FTLD, PD and AD.

Conditions

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Alzheimer's Disease Parkinson's Disease Frontotemporal Lobar Degeneration

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Alzheimer's disease

Observational Study

Observational Study

Intervention Type BEHAVIORAL

This is an observational study.

Parkinson's disease

Observational Study

Observational Study

Intervention Type BEHAVIORAL

This is an observational study.

Frontotemporal Lobar Degeneration

Observational Study

Observational Study

Intervention Type BEHAVIORAL

This is an observational study.

Healthy Controls

Observational Study

Observational Study

Intervention Type BEHAVIORAL

This is an observational study.

Interventions

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Observational Study

This is an observational study.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

Patients:

* ability to speak and understand the English language (as questionnaires and tests are only available in English)

Caregivers:

* primary caregiver for a given patient
* ability to speak and understand the English language (as questionnaires and tests are only available in English)

Exclusion Criteria

Patients and Caregivers:

* history of another neurological disorder
* psychiatric disorder
* severe aphasia (semantic word loss)
* visual deficits requiring correction beyond the use of eyeglasses or contact lenses (intact visual acuity is required for completing both the questionnaires and the emotion evaluation test which consists of video vignettes)
* auditory deficits requiring correction beyond hearing aids (videos have auditory component)

Patients:

* presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body will be excluded as they will be unable to have a MRI scan.
* premenopausal women will be excluded due to the unknown risk of MRIs during pregnancy.
Minimum Eligible Age

50 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Health Network, Toronto

OTHER

Sponsor Role lead

Responsible Party

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Carmela Tartaglia

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Maria C Tartaglia, M.D.

Role: PRINCIPAL_INVESTIGATOR

Toronto Western Hospital, UHN; Tanz CRND

Locations

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Toronto Western Hospital, University Health Network

Toronto, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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12-0451-BE

Identifier Type: -

Identifier Source: org_study_id