Cognition and NeuroImaging in neuroDegenerative Disorders (CogNID)
NCT ID: NCT03861884
Last Updated: 2024-03-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
125 participants
OBSERVATIONAL
2018-12-12
2025-03-31
Brief Summary
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1. to compare cognitive performance in different clinical groups of participants with mild cognitive impairment (MCI) or mild dementia \[Alzheimer's Disease (AD), Vascular Cognitive Impairment (VCI) and Fronto-temporal Dementia (FTD)\] to determine whether scores reveal differential profiles between the groups,
2. to demonstrate differences in imaging markers between different dementia syndromes and healthy volunteers using ultra high-field MRI at 7T.
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Detailed Description
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1. to demonstrate differences in brain iron levels between different dementia syndromes and healthy volunteers using ultra high-field MRI, quantitative susceptibility mapping (QSM) at 7T.
2. to demonstrate variations in the resting oxygen usage as an important biomarker to discriminate between different dementia syndromes.
3. to demonstrate cerebral blood flow changes in the brain, particularly in the hippocampus region, and its correlation with different dementia syndromes using Arterial Spin Labelling MRI technique.
4. to demonstrate increased blood brain barrier leakage in the brain, particularly in the hippocampus region, and its correlation with Alzheimer's Disease (AD) and Vascular Cognitive Impairment (VCI) using a new dynamic contrast-enhanced MRI (DCE-MRI) technique.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Cognitive assessments
Neurocognitive assessments, Birmingham Cognitive Screen
No interventions assigned to this group
MRI at 3T
Brain Imaging: MRI at 3T
Cognitive assessments
Cognitive assessment and MRI at 3T and/or 7T
MRI at 7T
Brain imaging: Ultrahigh Field MRI at 7T
Cognitive assessments
Cognitive assessment and MRI at 3T and/or 7T
Interventions
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Cognitive assessments
Cognitive assessment and MRI at 3T and/or 7T
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Either pathological, genetic or imaging biomarker evidence to suggest Fronto-temporal Lobar Degeneration, Alzheimer's Disease or Vascular Cognitive Impairment, or defined clinical diagnoses.
Exclusion Criteria
2. Not speaking English before age 5 years.
3. Learning disability.
4. MRI contraindications
18 Years
ALL
No
Sponsors
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Nottingham University Hospitals NHS Trust
OTHER
Responsible Party
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Principal Investigators
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Locations
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Nottinghamshire Healthcare NHS Foundation Trust
Nottingham, Easat Midland, United Kingdom
Nottingham University Hospitals NHS Trust
Nottingham, East Midland, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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18NS001
Identifier Type: -
Identifier Source: org_study_id
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