Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease

NCT ID: NCT04597827

Last Updated: 2023-08-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-10-16

Study Completion Date

2022-04-27

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study aims at exploring patients' ability to monitor their own memory performance depending on their primary deficit and the type of memory involved in the criterion task. The goal is to evaluate if semantic dementia (SD) and Alzheimer's disease (AD) differently affect patients' awareness of their memory abilities.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Patients who will give their informed non-opposition will be included. Participants will undergo 6 metacognitive tasks in which they will be tested on newly learnt information (i.e., episodic memory) or prior knowledge (i.e., semantic memory) and asked to evaluate their performance either prior or after the test. Correlation between their evaluation and their actual performance will be measured. Performance and correlations will be compared across groups.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Semantic Dementia Alzheimer Disease Healthy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Semantic dementia

Diagnosis of semantic dementia (revised criteria Moreaud et al., 2008; based on Neary et al., 1998)

Metacognition tests

Intervention Type OTHER

Test on episodic or semantic memory

Alzheimer's disease

NIAAA 2011 criteria

Metacognition tests

Intervention Type OTHER

Test on episodic or semantic memory

Control

MMSE above 27, no neurological or psychiatric disorder

Metacognition tests

Intervention Type OTHER

Test on episodic or semantic memory

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Metacognition tests

Test on episodic or semantic memory

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* native French-speakers
* normal or corrected-to-normal vision
* for patients ONLY : doctor-approved diagnosis of semantic dementia or Alzheimer's disease
* for healthy participants ONLY: score above 27 on the MMSE
* non-opposition in participation

Exclusion Criteria

* other neurological/ psychiatric disorder, or cognitive disorder that might affect general cognition
* drug or alcohol abuse
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Olivier MOREAUD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Grenoble

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

CHU Angers

Angers, , France

Site Status

CHU Bordeaux

Bordeaux, , France

Site Status

Hôpital Neurologique de Lyon

Bron, , France

Site Status

Hôpitaux Civils Colmar

Colmar, , France

Site Status

Chu Grenoble Alpes

Grenoble, , France

Site Status

CHU Rennes

Rennes, , France

Site Status

CHU Vaudois

Lausanne, , Switzerland

Site Status

Countries

Review the countries where the study has at least one active or historical site.

France Switzerland

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2020-A02236-33

Identifier Type: OTHER

Identifier Source: secondary_id

38RC20.282

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Memory and Social Interactions
NCT05800028 RECRUITING
Detecting Dementia Earlier
NCT03900936 UNKNOWN
Self-consciousness in Dementia
NCT01782248 UNKNOWN NA