The China Longitudinal Aging Study of Cognitive Impairment

NCT ID: NCT03672448

Last Updated: 2020-01-10

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 10000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-09-01
• Study Completion Date: 2023-11-30

Brief Summary

Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly. The burden of dementia is rising in China, with major medical, social and economic impacts. To address this important public health problem, cohort study on elderly cognitive disorders should be carry out. The methods of early prevention, early diagnosis and early treatment the cognitive disorders in elderly should be found to reduce the burden of the social and economic issue due to dementia. At present, the international corresponding guidelines have taken gene and brain imaging biomarkers as important indicators of dementia pathogenesis research, accurate diagnosis and targeted intervention. Based on the above understanding, the study carry out the population cohort study based on accurate diagnosis and construct the high standard information and sample bank. The study will establish the standard and quality system of geriatric cognitive disorders cohort study (unified standards and norms). The study will integrate the standard biological samples stratified acquisition function module (homogeneity and precision) of elderly cognitive disorders, and complete the construction of biological samples bank and clinical diagnosis and treatment information database. The study will apply and develop brain structural and pathological imaging technology to support precision diagnosis of senile cognitive disorders. The study will evaluate whether peripheral nerve degeneration can predict central nervous system degeneration based on the large cohort of elderly study. In addition, The study will make an effective supplement the sample bank construction of Shanghai Mental Health Center.

Detailed Description

The neuropsychological test battery are used to access the cognitive function of subjects in the study. The brain MRI and biochemical examination will be done in the screening period. The samples such as plasma, serum, urine and faeces et al. of the subjects will be collected in the study.

Conditions

Mild Cognitive Impairment; Alzheimer Disease; Dementia, Vascular; Dementia With Lewy Bodies; Dementia Frontal; Depression; Anxiety

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Neurocognitive disorder

Dementias

Naturalistic observation

Intervention Type: OTHER

Naturalistic observation

Normal Aging

Normal Aging with normal cognitive function

Naturalistic observation

Intervention Type: OTHER

Naturalistic observation

Interventions

Naturalistic observation

Naturalistic observation

Intervention Type: OTHER

Other Intervention Names

Normal Aging

Eligibility Criteria

Inclusion Criteria

• registered residents in the community;
• ≥ 60 years;
• without schizophrenia or mental retardation;
• be able to communicate and accept physical and cognitive examinations

Exclusion Criteria

• blind
• deaf mute

• Minimum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Shanghai Mental Health Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Huafang Li, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Shanghai Mental Health Centre

Locations

Shanghai Mental Health Centre

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Shifu Xiao, M.D., Ph.D.

Role: CONTACT

xiaoshifu@msn.com

00862164387250 ext. 73441

Tao Wang, M.D., Ph.D.

Role: CONTACT

wtshhwy@163.com

00862164387250 ext. 73220

Facility Contacts

Shifu Xiao, M.D., Ph.D.

Role: primary

References

Wang T, He H, Shi Y, Su N, Zhu M, Yan F, Liu Y, Li J, Tang M, Chen W, Bao F, Wang H, Wang Y, Liu Y, Yuan Y, Zuo X, Zhang X, Cui L, Wu W, Zhang C, Lu Y, Fang Y, Xiao S. Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China. Gen Psychiatr. 2025 Mar 7;38(2):e101736. doi: 10.1136/gpsych-2024-101736. eCollection 2025.

Reference Type: DERIVED

PMID: 40070969 (View on PubMed)

Other Identifiers

CRC2017ZD02

Identifier Type: -

Identifier Source: org_study_id