Self-consciousness in Dementia

NCT ID: NCT01782248

Last Updated: 2020-09-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

65 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-03-13

Study Completion Date

2022-03-12

Brief Summary

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The aim of this study is to characterize the deficit in critical components of personal identity (self-consciousness and social cognition) in patients with Alzheimer's disease (AD) and fronto-temporal lobar dementia (FTLD), compared to healthy elderly, combining a neuropsychology and multi-podal neuroimaging study.

We posit that the alteration of some aspects of self-consciousness (autobiographical memory, nosognosia, metacognition) and social cognition (theory of mind and facial) results in personality changes in the patients, primarily due to the alteration of self-consciousness in AD and to social cognition in FTLD.

Detailed Description

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Conditions

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Alzheimer Disease Fronto-temporal Lobar Dementia

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Alzheimer disease

Patients with Alzheimer disease

Group Type OTHER

Questionnary and IRM

Intervention Type OTHER

Fronto-temporal lobar dementia

Patients with Fronto-temporal lobar dementia

Group Type OTHER

Questionnary and IRM

Intervention Type OTHER

Control

Control group

Group Type OTHER

Questionnary and IRM

Intervention Type OTHER

Interventions

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Questionnary and IRM

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* AD (McKhann et al, 1984 and Dubois et al, 2007) or FTLD (Neary et al, 1998 or Rascovsky et al, 2011)
* MMSE \> or = 18
* Relative avaible

Exclusion Criteria

* Contraindication to MRI
* Major depression
* Other central neurological condition
Minimum Eligible Age

45 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hôpitaux Universitaires de Strasbourg

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Nathalie PHILIPPI, MD

Role: CONTACT

3 88 12 86 33 ext. +33

Facility Contacts

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Nathalie PHILIPPI, MD

Role: primary

3 88 12 86 33 ext. +33

Other Identifiers

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5289

Identifier Type: OTHER

Identifier Source: secondary_id

5289

Identifier Type: -

Identifier Source: org_study_id

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