Autobiographical Specificity

NCT ID: NCT05642351

Last Updated: 2024-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

62 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-02-03

Study Completion Date

2025-12-03

Brief Summary

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Autobiographical memory is diminished in patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia, and research has focused on the hampered ability of patients in retrieving specific memories. However, this study proposes a detailed methodology to provide a qualitative analysis of autobiographical specificity.

Detailed Description

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Patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia will be invited to retrieve autobiographical memories. Memories will be analyzed and categorized into specific, categoric, extended, or semantic autobiographical retrieval.

Conditions

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Memory Alzheimer Disease Frontotemporal Dementia

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Alzheimer's Disease

recruited according to criteria by National Institute on Aging (McKhann et al., 2011).

Autobiographical reminder

Intervention Type OTHER

The analysis of the specificity of Autobiographical Recall will be done through the following scale, developed for the study:

* 6 points for a recall involving a single personal event located in space AND time (e.g.,"I remember when my parents took me to the sea for the first time..in 1962..in Dunkerque")
* 5 points for a recall involving a single personal event located in space OR time ("I remember when my parents first took me to the sea...in 1962")
* 4 points for a recall involving a single personal event but without spatial/temporal details ("I remember when my parents took me to the sea for the first time")
* 3 points for a recall involving a general personal event but located in space AND time ("we used to go to Dunkerque in the summer")
* 2 points for a recall involving a general personal event but located in space OR time ("we used to go to Dunkerque")
* 1 point for a recall involving a general personal event without spatial/temporal details ("we used to go on vacation")

Behavioral variant of frontotemporal dementia

recruited following criteria by Rascovsky et al. (2011)

Autobiographical reminder

Intervention Type OTHER

The analysis of the specificity of Autobiographical Recall will be done through the following scale, developed for the study:

* 6 points for a recall involving a single personal event located in space AND time (e.g.,"I remember when my parents took me to the sea for the first time..in 1962..in Dunkerque")
* 5 points for a recall involving a single personal event located in space OR time ("I remember when my parents first took me to the sea...in 1962")
* 4 points for a recall involving a single personal event but without spatial/temporal details ("I remember when my parents took me to the sea for the first time")
* 3 points for a recall involving a general personal event but located in space AND time ("we used to go to Dunkerque in the summer")
* 2 points for a recall involving a general personal event but located in space OR time ("we used to go to Dunkerque")
* 1 point for a recall involving a general personal event without spatial/temporal details ("we used to go on vacation")

Interventions

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Autobiographical reminder

The analysis of the specificity of Autobiographical Recall will be done through the following scale, developed for the study:

* 6 points for a recall involving a single personal event located in space AND time (e.g.,"I remember when my parents took me to the sea for the first time..in 1962..in Dunkerque")
* 5 points for a recall involving a single personal event located in space OR time ("I remember when my parents first took me to the sea...in 1962")
* 4 points for a recall involving a single personal event but without spatial/temporal details ("I remember when my parents took me to the sea for the first time")
* 3 points for a recall involving a general personal event but located in space AND time ("we used to go to Dunkerque in the summer")
* 2 points for a recall involving a general personal event but located in space OR time ("we used to go to Dunkerque")
* 1 point for a recall involving a general personal event without spatial/temporal details ("we used to go on vacation")

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Alzheimer' disease or avioral variant of frontotemporal dementia
* No opposition from the patient to be included in the study
* For Alzheimer's patients: a score of more than 24 out of 30 on the Mini Mental State Examination (McKhann et al., 1984)

Exclusion Criteria

* Other psychiatric/neurological disorders
* Minor patients
* Adults under guardianship or protection.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nantes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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EL HAJ Mohamad

Nantes, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Mohamad EL HAJ

Role: CONTACT

02 40 68 66 60

Claire Boutoleau Bretonnière

Role: CONTACT

02 40 16 57 05

Facility Contacts

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Mohamad EL HAJ

Role: primary

02 40 68 66 60

Mohamad EL HAJ

Role: backup

Claire BOUTOLEAU BRETONNIERE

Role: backup

Other Identifiers

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RC22_0626

Identifier Type: -

Identifier Source: org_study_id

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