Comparison of Effectiveness and Costs of Post-diagnosis Treatment in Dementia
NCT ID: NCT00554047
Last Updated: 2011-01-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
220 participants
INTERVENTIONAL
2007-12-31
2010-07-31
Brief Summary
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Objectives: To determine MMCs' effectiveness and cost-effectiveness in post-diagnosis treatment and care-coordination for dementia-patients and their caregivers compared to the post-diagnosis treatment and care coordination by GPs.
Time schedule: 12 months for including patients and their caregivers and 12 months of follow-up.
Annex Study: Specifically for the Health Technology Assessment (HTA) methodology study the main study will be extended with some experimental proxy measurements and alternative measurement approaches.
The objective of this Annex-study is to explore the feasibility and validity of Health Related Quality of Life (HRQL) value measurement in dementia patients. And to study the characteristics of proxy rating in HRQL research in dementia and the suitability and validity of yielding HRQL measurements by proxy assessment. Furthermore to explore the validity, reliability, and feasibility of the EQ5D and EQ6D in dementia research (in patients and in/by proxies); response shift, and alternative (more simple) methods of HRQL measurement and validate the Dutch versions of the QOL-AD and the use of the CarerQol-7D in dementia research.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
SINGLE
Study Groups
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1
Multidisciplinary Memory Clinic
Multidisciplinary Memory Clinic
Post-diagnosis treatment and coordination of care for patients with dementia and their informal caregivers delivered by Multidisciplinary Memory Clinics (MMCs)
2
General practitioner
General Practitioners
Post-diagnosis treatment and coordination of care for patients with dementia and their informal caregivers delivered by general practitioners
Interventions
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Multidisciplinary Memory Clinic
Post-diagnosis treatment and coordination of care for patients with dementia and their informal caregivers delivered by Multidisciplinary Memory Clinics (MMCs)
General Practitioners
Post-diagnosis treatment and coordination of care for patients with dementia and their informal caregivers delivered by general practitioners
Eligibility Criteria
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Inclusion Criteria
* Each patient has a caregiver
* Both patients and caregivers can provide informed consent for participation in the study
Exclusion Criteria
* Living in a nursing home
* Already evaluated as being suitable for living in a nursing home
* Data collection impossible (e.g., due to severe visual/hearing/language impairment, mood disorder, or behavioral disturbances)
* The patient's general practitioner does not agree to participate
* Already participating in another study
* The patient visits the MMC for a second opinion
* Travel distance between MMC and patient's living address more than 50 kilometers
* A definite indication for memory clinic follow up:
* A definite need for symptomatic drug treatment as judged by treating physician (e.g., Dementia with Lewy Bodies)
* A definite need for specialist guidance as judged by treating physician (e.g., Creutzfeldt-Jakob Disease, severe Frontotemporal Lobar Disease)
* A definite wish for symptomatic drug treatment by patient or caregiver
* A definite need for guidance from psychiatric services involved in the memory clinic
ALL
No
Sponsors
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ZonMw: The Netherlands Organisation for Health Research and Development
OTHER
Netherlands Alzheimer Foundation
OTHER
Amsterdam UMC, location VUmc
OTHER
Maastricht University Medical Center
OTHER
Karolinska Institutet
OTHER
Stockholm Health Economics AB
UNKNOWN
Slingeland Hospital
OTHER
Elkerliek Hospital
OTHER
Ggz Oost Brabant
OTHER
Rijnstate Hospital
OTHER
Radboud University Medical Center
OTHER
Principal Investigators
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Prof. Dr. M. Olde Rikkert, MD PhD
Role: PRINCIPAL_INVESTIGATOR
University Medical Centre St Radboud, Nijmegen
Locations
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VU Medical Center, Alzheimer Centre
Amsterdam, , Netherlands
Alysis Zorgroep, Rijnstate Hospital, Department of Geriatrics
Arnhem, , Netherlands
GGZ Oost Brabant, Department of Geriatrics
Boxmeer, , Netherlands
Slingeland Hospital, Department of Geriatrics
Doetinchem, , Netherlands
Hospital Gelderse Vallei, Department of Geriatrics
Ede, , Netherlands
Catharina hospital, Department of Geriatrics
Eindhoven, , Netherlands
Elkerliek Hospital, Department of Geriatrics
Helmond, , Netherlands
University Hospital Maastricht, Alzheimer Centre
Maastricht, , Netherlands
University Medical Centre St Radboud, Alzheimer Centre
Nijmegen, , Netherlands
Countries
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References
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Meeuwsen E, Melis R, van der Aa G, Goluke-Willemse G, de Leest B, van Raak F, Scholzel-Dorenbos C, Verheijen D, Verhey F, Visser M, Wolfs C, Adang E, Olde Rikkert M. Cost-effectiveness of one year dementia follow-up care by memory clinics or general practitioners: economic evaluation of a randomised controlled trial. PLoS One. 2013 Nov 25;8(11):e79797. doi: 10.1371/journal.pone.0079797. eCollection 2013.
Meeuwsen EJ, Melis RJ, Van Der Aa GC, Goluke-Willemse GA, De Leest BJ, Van Raak FH, Scholzel-Dorenbos CJ, Verheijen DC, Verhey FR, Visser MC, Wolfs CA, Adang EM, Olde Rikkert MG. Effectiveness of dementia follow-up care by memory clinics or general practitioners: randomised controlled trial. BMJ. 2012 May 15;344:e3086. doi: 10.1136/bmj.e3086.
Meeuwsen EJ, German P, Melis RJ, Adang EM, Goluke-Willemse GA, Krabbe PF, de Leest BJ, van Raak FH, Scholzel-Dorenbos CJ, Visser MC, Wolfs CA, Vliek S, Rikkert MG. Cost-effectiveness of post-diagnosis treatment in dementia coordinated by Multidisciplinary Memory Clinics in comparison to treatment coordinated by general practitioners: an example of a pragmatic trial. J Nutr Health Aging. 2009 Mar;13(3):242-8. doi: 10.1007/s12603-009-0066-1.
Other Identifiers
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ZonMw 80-007022-98-07703
Identifier Type: -
Identifier Source: secondary_id
ZonMw 945-07-7039
Identifier Type: -
Identifier Source: secondary_id
ADE 072510
Identifier Type: -
Identifier Source: org_study_id
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