Remote Sensing for ADRD-Specific Activities Identification in Older Adults

NCT ID: NCT07120347

Last Updated: 2025-08-13

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-08-01
• Study Completion Date: 2027-07-31

Brief Summary

The investigators aim to use smart-home sensors and artificial intelligence (AI) to monitor and detect Alzheimer's Disease and Related Dementias (ADRD)-specific daily activities among older adults, with the goal of early symptom detection and personalized support. Dementia, which impacts memory and cognition, remains a global concern. In the United States, more than 6.7 million individuals aged 65 and older are living with ADRD, and projected annual healthcare costs are expected to reach $1 trillion by 2050. This underscores the need for deeper understanding and innovative support. To address the unique challenges associated with ADRD, such as cognitive decline, personalized strategies that promote independent well-being are essential. Smart-home sensors can support older adults with ADRD as they continue to live in their homes. These sensors provide real-time data on health and daily activities, offering insights into their daily lives. However, adoption of these technologies is low, and the practical application of AI remains limited. This highlights the need for further research to make these devices more accessible to this population. The investigators' aims include:

Conducting focus groups with individuals with and without ADRD and their caregivers to identify daily activities that can be measured using in-home sensors; Collecting in-home sensor data from older adults with and without ADRD; and Using AI to develop a tool for recognizing daily activities. The integration of smart-home sensors with advanced data-analysis techniques holds significant potential for transforming the support and care provided to individuals with ADRD. Ultimately, the investigators' findings will contribute to improving the quality of life for affected individuals and alleviating the burden on caregivers and healthcare systems.

Detailed Description

Dementia, which impacts memory and cognitive abilities, constitutes a global concern that intensifies with the aging population. In the United States, 6.7 million individuals aged 65 and older live with Alzheimer's Disease and Related Dementias (ADRD), and projected annual healthcare costs are expected to reach $1 trillion by 2050. This underscores the urgent need for enhanced understanding and innovative support. Individuals with ADRD face unique challenges, including behavioral changes and cognitive decline, necessitating tailored strategies for their well-being. Aligning with the National Institute on Aging's research goals, the investigators' study explores a promising avenue: the use of smart-home sensors to monitor and assist ADRD patients while they reside in their homes. These sensors provide real-time insights into health, activity, and environmental factors. However, adoption of these technologies among people with ADRD is low, and the practical application of artificial intelligence (AI) in this context remains limited. This underscores the need for further research to make these devices more accessible to this population.

The investigators aim to utilize a fully modular smart-home sensor system, combined with AI-based data-analysis methods, to monitor and analyze activities specific to individuals with ADRD. Remote sensor installations have been deployed across Missouri to facilitate the seamless delivery of sensor data to the investigators' interdisciplinary team, known as the Age-friendly Smart, Sustainable, and Equitable Technologies for Access intervention research team. The investigators' approach involves applying AI with causal inference to gain a nuanced understanding of the daily activities and behavioral patterns of those with ADRD. The investigators hypothesize that incorporating modeled causal features into the AI process will 1) enable identification of ADRD-specific daily activities, and 2) enhance the AI's ability to recognize these activities.

The investigators' aims include:

Conducting focus groups with individuals with and without ADRD and their caregivers to identify daily activities measurable with in-home sensors; Collecting in-home sensor data from older adults with and without ADRD; and Developing an AI system using machine-learning (ML) models for ADRD-specific daily activity recognition. Aim 3 will encompass three key elements: identification of causal features associated with ADRD-specific daily activities, development and refinement of ML models for recognizing these activities informed by the causal features, and creation of personalized ML models for individuals diagnosed with ADRD.

The integration of smart-home sensors with advanced data-analysis techniques holds significant potential for transforming the support and care provided to individuals with ADRD. Ultimately, the investigators' findings will contribute to improving the quality of life for affected individuals and alleviating the burden on caregivers and healthcare systems.

Conditions

Alzheimer Disease and Related Dementias (ADRD); Mild Cognitive Impairment (MCI)

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: SINGLE

Study Groups

Pariticpants w/ ADRD

Group Type: EXPERIMENTAL

Remote Ambient Sensor System

Intervention Type: OTHER

Remote sensors (motion, door contact) deployed in participants' home connected through raspberry pi and mobile hotspot

Participants w/o ADRD

Group Type: ACTIVE_COMPARATOR

Remote Ambient Sensor System

Intervention Type: OTHER

Remote sensors (motion, door contact) deployed in participants' home connected through raspberry pi and mobile hotspot

Interventions

Remote Ambient Sensor System

Remote sensors (motion, door contact) deployed in participants' home connected through raspberry pi and mobile hotspot

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Community-dwelling, English-speaking adults aged ≥ 50 years
• Clinical diagnosis of mild cognitive impairment or mild dementia (ADRD)
• Diagnosis established by a neuropsychologist, neurologist, or geriatrician within the University of Missouri Healthcare System
• Diagnosis confirmed using the latest consensus criteria and verified through record review
• No restriction on the etiology of the cognitive disorder (e.g., Alzheimer's disease, vascular dementia, mixed dementia)

Exclusion Criteria

• Clinical Dementia Rating (CDR) global score > 1 (moderate or severe dementia)
• Cognitive or functional impairments that would preclude meaningful participation in daily activities

• Minimum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Missouri-Columbia

OTHER

Sponsor Role: lead

Responsible Party

Knoo Lee

Ast Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University of Missouri

Columbia, Missouri, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Knoo Lee, PhD

Role: CONTACT

knoolee@missouri.edu

5738840421

Facility Contacts

Knoo Lee, PhD

Role: primary

knoolee@missouri.edu

5738840421

Other Identifiers

24AARGD-NTF-1242722

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

2101666

Identifier Type: -

Identifier Source: org_study_id