Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
60 participants
OBSERVATIONAL
2024-07-01
2030-12-29
Brief Summary
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The main questions the study aims to answer are:
1. What findings can be used to earlier detect patients that will develop Alzheimers?
2. Which differences are seen between healthy and cognitively impaired patients?
3. Which differences are seen between patients with Alzheimers disease?
Participants will undergo:
* Cognitive tests
* Magnetic resonance imaging (MRI)
* Electroencephalography (EEG)
* Blood sample collection
* Fecal sample collection
* A randomized group will undergo polysomnography analysis.
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Detailed Description
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In the MRI, researchers will get the opportunity to analyse both structural and functional brain changes. In the EEG, changes in elctrical activites will be measured. The blood samples allow researchers to analyse specific dementia and inflammation proteins, while fecal speciments can be used to assess bacterial composition. Additionally, the cognitive testing allow to assess the specific part of cognitive function which is affected.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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MCI
Recruitment according to relevant clinical assessment and ICD-criterias.
MRI Scanning
MRI scanning with volumetric, resting and activity-based sequences.
64-channel EEG
EEG to quantifiy electric activity.
Polysomnography
A randomized group will undergo polysomnography.
Blood samples
Analysis of specific blood biomarkers.
Fecal samples
Analysis of bacterial composition.
Cognitive tests
Interview-based cognitive tests for assesment of cognitive levels.
Mild AD
Recruitment according to relevant clinical assessment and ICD-criterias.
MRI Scanning
MRI scanning with volumetric, resting and activity-based sequences.
64-channel EEG
EEG to quantifiy electric activity.
Polysomnography
A randomized group will undergo polysomnography.
Blood samples
Analysis of specific blood biomarkers.
Fecal samples
Analysis of bacterial composition.
Cognitive tests
Interview-based cognitive tests for assesment of cognitive levels.
Control
Equivalent number of research participants as in the MCI and mild AD group.
MRI Scanning
MRI scanning with volumetric, resting and activity-based sequences.
64-channel EEG
EEG to quantifiy electric activity.
Polysomnography
A randomized group will undergo polysomnography.
Blood samples
Analysis of specific blood biomarkers.
Fecal samples
Analysis of bacterial composition.
Cognitive tests
Interview-based cognitive tests for assesment of cognitive levels.
Interventions
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MRI Scanning
MRI scanning with volumetric, resting and activity-based sequences.
64-channel EEG
EEG to quantifiy electric activity.
Polysomnography
A randomized group will undergo polysomnography.
Blood samples
Analysis of specific blood biomarkers.
Fecal samples
Analysis of bacterial composition.
Cognitive tests
Interview-based cognitive tests for assesment of cognitive levels.
Eligibility Criteria
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Inclusion Criteria
* Control cohort is age and gender matched with other cohorts.
Exclusion Criteria
* AD diagnosis before the age of 65 (Early-onset AD).
* Brain tumor
* Traumtic head injury
* Earlier neurosurgery
* Other neyrodegenerative diseases (i.e Parkinson and ALS)
* Diseases related to inflammation and auto-immunity (i.e MS)
65 Years
ALL
Yes
Sponsors
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Norwegian University of Science and Technology
OTHER
Responsible Party
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Principal Investigators
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Axel Sandvig, Prof., MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Norwegian University of Science and Technology (NTNU) & St. Olavs Hospital, Trondheim University Hospital
Locations
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Norwegian University of Sciene and Technology / Norges teknisk-naturvitenskapelige universitet (NTNU)
Trondheim, Trønderlag, Norway
Countries
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Central Contacts
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Other Identifiers
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626476
Identifier Type: -
Identifier Source: org_study_id
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