Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2023-11-01
2024-01-30
Brief Summary
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Diabetes mellitus is the name given to a wide spectrum group of disorders characterized by raised plasma glucose.Type 1 diabetes is characterized by an absolute insulin deficiency due to autoimmune destruction of insulin producing beta cells in the pancreas.
most adults with diabetes have type 2, characterized by a relative insulin secretory defect, and target tissue resistance to the effects of insulin.
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Detailed Description
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Type 2 diabetes mellitus is a common and increasingly prevalent disease and is thus a major public health concern worldwide. The International Diabetes Federation estimates that there are approximately 387 million people diagnosed with diabetes across the globe.
The clinical diagnosis of diabetes is reliant on either one of the four plasma glucose (PG) criteria: elevated (i) fasting plasma glucose (FPG) (\>126 mg/dL), (ii) 2 h PG during a 75-g oral glucose tolerance test (OGTT) (\>200 mg/dL), (iii) random PG (\>200 mg/dL) with classic signs and symptoms of hyperglycemia, or (iv) hemoglobin A1C level \>6.5%.
The principal tissues affected by insulin resistance are liver, muscle and fat. In the liver this impaired insulin related inhibition of hepatic gluconeogenesis results in increased hepatic glucose output, exacerbating hyperglycemia.
In muscle, reduced transport of carbohydrates into muscle combined with lipid deposition in muscle cells leads toimpaired exercise ability and lowered threshold for tiredness with exercise. In fat tissue, there is impaired insulin-mediated inhibition of hormone dependent lipase, with breakdown of lipids to free fatty acids and glycerol, contributing to the dyslipidemia. With the rise in diabetes prevalence, researchers have increasingly investigated treatments intended to improve health and quality of life. People are much more likely to achieve metabolic control when they adhere to recommended diets, medications and exercise behaviors.
Cryolipolysis (CoolSculpting, Zeltiq, Pleasanton, CA) is a novel method of selective removal of fat with cooling. This technique is basedon the concept that fat cells are more sensitive to cold than the surrounding tissue. Prior studies and observations have demonstrated that cold exposure can induce selective damage to the subcutaneous fat via induction of panniculitis, resulting in reduction in the superficial fat layer of the skin
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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Cryolipolysis Group
About 30 obese females with type 2 diabetes and will face cryolypolysis in addition to exercise therapy treatment
Cryolipolysis
To investigate the Effect of Cryolipolysis On insulin resistance and In adult type 2 female patients.
Group of Exercise
About 30 obese females with type 2 diabetes and will face exercise therapy treatment only.
Cryolipolysis
To investigate the Effect of Cryolipolysis On insulin resistance and In adult type 2 female patients.
Interventions
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Cryolipolysis
To investigate the Effect of Cryolipolysis On insulin resistance and In adult type 2 female patients.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patient fasting glucose level is more than 140 mg/dL.
* Age will be ranged from 35 to 45 years
* Body mass index between 25 and 30.
* All patients are medically controlled
* All patients have the same medical care.
* All patients will receive a good explanation of treatment procedures.
Exclusion Criteria
* Renal failure.
* Myocardial infractions.
* Cardiovascular problems.
* Neurological disorders.
* Patients with orthopedic problems (e.g mal or incomplete union of fracture, ankle sprains.
* Abdominal hernia
* Skin disease
* Unstable cases
35 Years
45 Years
FEMALE
No
Sponsors
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Cairo University
OTHER
Responsible Party
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Noura Ramadan Fahmy
Resident of Physical therapy
Principal Investigators
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Akram Abd El Aziz, Assist.Prof
Role: STUDY_CHAIR
Cairo University
Locations
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Faculty of Physical Therapy, Cairo University
Cairo, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Noura Fahmy
Identifier Type: -
Identifier Source: org_study_id
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