Role of Adipose Tissue in Pathogenesis of Insulin Resistance

NCT ID: NCT00439491

Last Updated: 2007-02-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-01-31

Study Completion Date

2006-12-31

Brief Summary

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The aim of the study was to investigate the relationship between insulin resistance and body composition in relation to secterion and expression of adipocytokines. Obese subjects undergo 6 months hypocaloric diet and, before, during and at the end of the diet, plasma samples and subcutaneous adipose tissue samples are obtained for subsequent analysis. In addition, body composition and insulin resistance are measured before and during the diet.

Detailed Description

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The aim of the study was to investigate the relationship between insulin resistance and body composition in relation to secterion and expression of adipocytokines. Obese subjects undergo 6 months hypocaloric diet without any medication and, before, during and at the end of the diet, plasma samples and subcutaneous adipose tissue samples are obtained for subsequent analysis. Adipose tissue samples are obtained using needle biopsy. In addition, before and during the diet,body composition is measured using multifrequency bioimpedance and insulin resistance is evaluated using either hyperinsulinemic clamp or glucose/insulin - derived indices.

Conditions

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Obesity Insulin Resistance

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Interventions

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Hypocaloric diet

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Obesity

Exclusion Criteria

* Diabetes
* Coronary heart disease
* Eating disorders
* Medication of beta blockers
* Medication of antiobesity drugs
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Charles University, Czech Republic

OTHER

Sponsor Role lead

Principal Investigators

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Vladimir Stich, Ass Prof MD PhD

Role: PRINCIPAL_INVESTIGATOR

Third Faculty of Medicine, Charles Uniersity in Prague

Locations

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Third Faculty of Medicine, Charles University in Prague

Prague, , Czechia

Site Status

Countries

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Czechia

Related Links

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http://www.lf3.cuni.cz

web page of the Third Faculty of Medicine

Other Identifiers

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303040158

Identifier Type: -

Identifier Source: org_study_id

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