Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2015-10-01
2018-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Metformin oral +exercise
Metformin, one dose 2000mg, 2.5h before the start of 60 min physical exercise
Metformin Oral
Exercise
Metformin local in AT +exercise
Metformin perfused into microdialysis probe inserted in adipose tissue, 0.3ug/min 1.5h before the exercise and during 60min physical exercise
Metformin local in AT
Exercise
No metformin + exercise
60min physical exercise without pretreatment of metformin
Exercise
Interventions
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Metformin Oral
Metformin local in AT
Exercise
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* hypertension,
* impaired fasting glucose
* diabetes
* hyperlipidemia
* drug or alcohol abuse
* smoking
25 Years
45 Years
MALE
Yes
Sponsors
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Charles University, Czech Republic
OTHER
Responsible Party
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Vladimir Stich
Professor, MUDr
Principal Investigators
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Vladimir Stich, prof
Role: STUDY_CHAIR
Third faculty of medicine, Charles University in Prague
Locations
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Third Faculty of Medicine, Charles University
Prague, , Czechia
Countries
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References
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Bourron O, Daval M, Hainault I, Hajduch E, Servant JM, Gautier JF, Ferre P, Foufelle F. Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase. Diabetologia. 2010 Apr;53(4):768-78. doi: 10.1007/s00125-009-1639-6. Epub 2009 Dec 31.
Flechtner-Mors M, Ditschuneit HH, Jenkinson CP, Alt A, Adler G. Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study. Diabet Med. 1999 Dec;16(12):1000-6. doi: 10.1046/j.1464-5491.1999.00189.x.
Ren T, He J, Jiang H, Zu L, Pu S, Guo X, Xu G. Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol. J Mol Endocrinol. 2006 Aug;37(1):175-83. doi: 10.1677/jme.1.02061.
Other Identifiers
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15-03139S
Identifier Type: -
Identifier Source: org_study_id
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