Family, Responsibility, Education, Support, and Health for Food Responsiveness

NCT ID: NCT06207110

Last Updated: 2025-05-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

280 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-04-03

Study Completion Date

2029-01-01

Brief Summary

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The objective of this proposed study is to compare Regulation of Cues (ROC), Family-Based Treatment (FBT), ROC+ nutrition education and reducing energy intake (ROC+) and a health education comparator (HE) for children with overweight or obesity who are high on food responsiveness (FR).

Detailed Description

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The investigators have developed a new model for the treatment of obesity, called Regulation of Cues (ROC), which is based on Behavioral Susceptibility Theory. The ROC program targets two theorized mechanisms for overeating; decreased sensitivity to appetitive cues and increased sensitivity to external food cues. Considering that FBT has merit for some children, but not all, this study will compare ROC to FBT, ROC with nutrition education and reducing energy intake (ROC+), and Health Education (HE). Treatment will consist of weekly individual sessions for the first 16 sessions, then twice per month for the final 2 months for a total of 20 sessions. The investigators will recruit children ages 7-12 with overweight or obesity who are high in food responsiveness (FR) and their parent and will conduct assessments at baseline, post-treatment (month 6), 6-month follow-up (month 12) and 12-month follow-up (month 18).

Conditions

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Obesity, Childhood

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Regulation of Cues

The ROC program provides psychoeducation, coping skills, self-monitoring and experiential learning targeting increasing satiety responsiveness and decreasing food cue responsiveness.

Group Type EXPERIMENTAL

Regulation of Cues

Intervention Type BEHAVIORAL

ROC is based on the Behavioral Susceptibility Theory and designed to incorporate psychoeducation, cue-exposure treatment, appetite awareness training, coping skills, and self-monitoring of satiety and cravings to improve satiety responsiveness and decrease food cue responsiveness. This arm will include an experiential component, including hunger monitoring during a meal or snack and participating in exposure exercises.

Family-Based Treatment

The FBT program provides nutrition and physical activity education, behavior therapy skills, and parenting skills targeting changes in energy balance.

Group Type ACTIVE_COMPARATOR

Family Based Behavioral Treatment

Intervention Type BEHAVIORAL

FBT provides nutrition and physical activity education, behavior therapy skills, and parenting skills targeting changes in energy balance.

Regulation of Cues +

The ROC+ program includes all of the components of ROC as well as nutrition education and reducing energy intake

Group Type EXPERIMENTAL

Regulation of Cues +

Intervention Type BEHAVIORAL

ROC+ includes all of the skills provided in ROC but integrates nutrition education and reducing energy intake

Health Education

The HE program provides information about nutrition, physical activity, sedentary behavior, sleep, emotions, and stress.

Group Type ACTIVE_COMPARATOR

Health Education

Intervention Type BEHAVIORAL

The HE program provides information about nutrition, physical activity, sedentary behavior, sleep, emotions, and stress.

Interventions

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Regulation of Cues

ROC is based on the Behavioral Susceptibility Theory and designed to incorporate psychoeducation, cue-exposure treatment, appetite awareness training, coping skills, and self-monitoring of satiety and cravings to improve satiety responsiveness and decrease food cue responsiveness. This arm will include an experiential component, including hunger monitoring during a meal or snack and participating in exposure exercises.

Intervention Type BEHAVIORAL

Family Based Behavioral Treatment

FBT provides nutrition and physical activity education, behavior therapy skills, and parenting skills targeting changes in energy balance.

Intervention Type BEHAVIORAL

Regulation of Cues +

ROC+ includes all of the skills provided in ROC but integrates nutrition education and reducing energy intake

Intervention Type BEHAVIORAL

Health Education

The HE program provides information about nutrition, physical activity, sedentary behavior, sleep, emotions, and stress.

Intervention Type BEHAVIORAL

Other Intervention Names

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ROC FBT ROC+ HE

Eligibility Criteria

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Inclusion Criteria

1. Informed assent and parental consent
2. A child with overweight or obesity (≥ 85th BMI%) aged 7-12 years of age
3. Child high on FR - High FR will be measured by the Food Responsiveness Scale via the CEBQ, with scores at a 3.8 or higher constituting a child with high FR.
4. A parent responsible for food preparation who is willing to participate and can read, speak and understand English at a minimum of a 5th grade level
5. Family is willing to commit to attending all assessment and treatment sessions, agree to be randomized and participate in all aspects of potential treatments
6. Child is on stable medication regimen for medications that can impact weight (3+ months)
7. Child does not have medical conditions that limit ability to participate in physical activity for the duration of the study. Parent can participate in physical activity with their child or provide opportunities for the child to complete recommended physical activity

Exclusion Criteria

1. Acute child psychiatric disorder diagnoses (e.g., acute suicidality, recent hospitalization, psychosis, bulimia nervosa)
2. Child diagnoses of a serious chronic physical disease (e.g., cystic fibrosis, type 1 diabetes) for which physician supervision of diet and exercise prescription may be warranted
3. Child who is taking medication for weight loss
4. Acute parent psychiatric disorder (e.g., acute suicidality; recent hospitalization; psychosis, bipolar disorder, borderline personality disorder, moderate or severe alcohol or substance use disorder)
5. First degree relative or someone in the household with anorexia or bulimia nervosa.

Potential participants with medical or psychological diagnosis that could make adherence with the study protocol difficult or dangerous will not be included.
Minimum Eligible Age

7 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Minnesota

OTHER

Sponsor Role collaborator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role collaborator

University of California, San Diego

OTHER

Sponsor Role lead

Responsible Party

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Kerri Boutelle

Kerri Boutelle, Ph.D.,, Professor of Pediatrics, Psychiatry, and Herbert Wertheim School of Public Health and Human Longevity Science

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kerri Boutelle, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

UC San Diego

Locations

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UC San Diego Center for Healthy Eating and Activity Research (CHEAR)

La Jolla, California, United States

Site Status RECRUITING

Ambulatory Research Center - University of Minnesota

Minneapolis, Minnesota, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Kaylen Moline, MPH

Role: CONTACT

1-855-827-3498

Kerri Boutelle, Ph.D.

Role: CONTACT

858-249-3528

Facility Contacts

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Kaylen Moline, MPH

Role: primary

1-855-827-3498

Carol Peterson, Ph.D.

Role: primary

612-273-9811

Related Links

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Other Identifiers

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1R01DK135599

Identifier Type: NIH

Identifier Source: secondary_id

View Link

806055

Identifier Type: -

Identifier Source: org_study_id

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