Genetic Predisposition to Food Cue Reactivity in Children
NCT ID: NCT03766191
Last Updated: 2024-11-21
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Clinical Phase
NA
Total Enrollment
189 participants
Study Classification
INTERVENTIONAL
Study Start Date
2019-01-10
Study Completion Date
2024-03-27
Brief Summary
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This study assesses the associations between genetic factors, food-cue-related neural reactivity, self-regulatory capacity, eating in the absence of hunger (EAH), and adiposity gain in children.
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Detailed Description
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The investigators will assess the associations between genetic factors, food-cue-related neural reactivity, eating in the absence of hunger (EAH) in response to food cues, and adiposity gain in children. They will also determine whether self-regulatory capacity modifies these associations. The genetic factors explored specifically include FTO, MC4R, polymorphisms in genes involved in dopaminergic pathways, and a composite genetic risk score built from genome-wide obesity-related loci.
\[3/14/2020\]: Study recruitment temporarily halted due to the COVID-19 pandemic
\[3/14/2020\]: Study recruitment temporarily halted due to the COVID-19 pandemic
Conditions
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Childhood Obesity
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
CROSSOVER
Primary Study Purpose
PREVENTION
Blinding Strategy
SINGLE
Participants
Study Groups
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Food Ads and fMRI
Exposure to food ads during an fMRI scan
Group Type
ACTIVE_COMPARATOR
Food Ads
Intervention Type
BEHAVIORAL
Exposure to foods ads embedded in an age-appropriate TV program
Non-Food Ads and fMRI
Exposure to non-food ads during an fMRI scan
Group Type
SHAM_COMPARATOR
Non-food Ads
Intervention Type
OTHER
Exposure to non-food ads embedded in an age-appropriate TV program
Food Ads and TV show
Exposure to food ads embedded in an age-appropriate TV program
Group Type
ACTIVE_COMPARATOR
Food Ads
Intervention Type
BEHAVIORAL
Exposure to foods ads embedded in an age-appropriate TV program
Non-Food Ads and TV show
Exposure to non-food ads embedded in an age-appropriate TV program
Group Type
SHAM_COMPARATOR
Non-food Ads
Intervention Type
OTHER
Exposure to non-food ads embedded in an age-appropriate TV program
Interventions
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Food Ads
Exposure to foods ads embedded in an age-appropriate TV program
Intervention Type
BEHAVIORAL
Non-food Ads
Exposure to non-food ads embedded in an age-appropriate TV program
Intervention Type
OTHER
Eligibility Criteria
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Inclusion Criteria
* English fluency
* Willingness to participate in all study visits
* Willingness to participate in all study visits
Exclusion Criteria
* Relevant food allergies or dietary restrictions
* Metal in or on the body
* Claustrophobia
* Psychiatric and neurological disorders
* Relative in the study
* Appetite- or attention-altering medications or disorders
* Metal in or on the body
* Claustrophobia
* Psychiatric and neurological disorders
* Relative in the study
* Appetite- or attention-altering medications or disorders
Minimum Eligible Age
8 Years
Maximum Eligible Age
12 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
Yes
Sponsors
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Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Sponsor Role
collaborator
Dartmouth College
OTHER
Sponsor Role
collaborator
Trustees of Dartmouth College
OTHER
Sponsor Role
lead
Responsible Party
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Diane Gilbert-Diamond
Associate Professor
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
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Diane Gilbert-Diamond, ScD
Role: PRINCIPAL_INVESTIGATOR
Dartmouth-Hitchcock Medical Center
Locations
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Dartmouth-Hitchcock
Lebanon, New Hampshire, United States
Site Status
Countries
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United States
References
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DERIVED
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
D19064
Identifier Type: -
Identifier Source: org_study_id
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PHASE2