Evaluate the Role of Soleus Muscle Exercise in Glycaemic Control in Diabetic Kidney Disease Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-18

Study Completion Date

2024-10-31

Brief Summary

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Evaluate the role of Soleus muscle exercise in management diabetic kidney disease

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Detailed Description

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management of diabetic kidney disease. To enhance their glycemic control, diabetic patients are advised to perform 150 minutes per week of moderate-to-vigorous aerobic activity Diabetic patients with regular physical activity have reduced daily insulin dose with more glycemic control. In addition to glycemic control, it has also been postulated that the addition of brief intervals of high intensity, sprint -type exercise to aerobic exercise can decrease the risk of late nocturnal hypoglycemic episodes Marc T. Hamilton et al., 2022, reported that the human soleus muscle could raise local oxidative metabolism to high levels for hours without fatigue, during a type of soleus-dominant activity while sitting (soleus push up exercise), even in unfit volunteers. They reported that soleus push up exercise can improve systemic VLDL-triglyceride and glucose homeostasis by a large magnitude, e.g., 52% less postprandial glucose excursion (∼50 mg/dL less between ∼1 and 2 h) with 60% less hyperinsulinemia. Muscle biopsies revealed there was minimal glycogen use. This can be explained that the soleus doesn't rely completely on intramuscular glycogen, Instead, it uses a mixture of fuels from glucose and lipoproteins.

Conditions

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Diabetic Kidney Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Soleus muscle exercise in diabetes

Soleus muscle decrease blood glucose

Group Type EXPERIMENTAL

Soleus ms exercise

Intervention Type DEVICE

Soleus muscle exercise before and after eating by half an hour

Decrease glucose level by soleus exercise

Soleus ms exercise in decrease blood glucose

Group Type EXPERIMENTAL

Soleus ms exercise

Intervention Type DEVICE

Soleus muscle exercise before and after eating by half an hour

Interventions

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Soleus ms exercise

Soleus muscle exercise before and after eating by half an hour

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients age 18-60 yrs.,
* patients with Diabetic kidney disease, not on dialysis
* with stabilized diabetic treatment regimen for 3 months before participating in the study

Exclusion Criteria

* advanced osteoarthritis of lower limb joints
* advanced poly neuropathic patients
* CKD type V on dialysis
* Diabetic Foot
* hemophilia
* bleeding tendency
* AKI
* other causes of chronic kidney disease
* patients refuse to participate in the study

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes