Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation.

NCT ID: NCT06109532

Last Updated: 2023-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

530 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-01

Study Completion Date

2023-10-31

Brief Summary

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Prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and November 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Detailed Description

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Background Dengue infection is becoming more prevalent worldwide and is associated with systemic inflammation. Systemic Inflammation is associated with non-osmotic release of ADH.

Methods: Participants conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and November 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Conditions

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Hyponatremia Dengue Inflammation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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DENGUE INFECTED PATIENTS. YEAR 2016

We conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and december 31, 2016. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

hyponatremia

Intervention Type OTHER

hyponatremia at admission in dengue infected patients

DENGUE INFECTED PATIENTS. YEAR 2020

We conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2020, and december 31, 2020. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

hyponatremia

Intervention Type OTHER

hyponatremia at admission in dengue infected patients

DENGUE INFECTED PATIENTS. YEAR 2023

We conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2023, and november 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

hyponatremia

Intervention Type OTHER

hyponatremia at admission in dengue infected patients

Interventions

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hyponatremia

hyponatremia at admission in dengue infected patients

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnosis confirmed by PCR, non structural protein 1 (NS1) antigen or IgM serology.

Plasma sodium at admission.

Exclusion Criteria

* None
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Nacional Profesor Alejandro Posadas

OTHER

Sponsor Role lead

Responsible Party

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Ladislao Diaz Ballve

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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CARLOS EGHI, MD

Role: PRINCIPAL_INVESTIGATOR

HOSPITAL NACIONAL PROF. A. POSADAS

Locations

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Ladislao Diaz Ballve

Haedo, Buenos Aires, Argentina

Site Status RECRUITING

Hospital Posadas

Buenos Aires, , Argentina

Site Status RECRUITING

Countries

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Argentina

Central Contacts

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CARLOS EGHI, MD

Role: CONTACT

+541166939309

LADISLAO DIAZ BALLVE, PHD

Role: CONTACT

Facility Contacts

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Ladislao P Diaz-Ballve, Lic.

Role: primary

+54(011)67887437

CARLOS EGHI, PHYSICIAN

Role: primary

+541166939309

References

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Ayus JC, Negri AL, Moritz ML, Lee KM, Caputo D, Borda ME, Go AS, Eghi C. Hyponatremia, Inflammation at Admission, and Mortality in Hospitalized COVID-19 Patients: A Prospective Cohort Study. Front Med (Lausanne). 2021 Dec 2;8:748364. doi: 10.3389/fmed.2021.748364. eCollection 2021.

Reference Type BACKGROUND
PMID: 34926496 (View on PubMed)

Other Identifiers

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HINDIP162023

Identifier Type: -

Identifier Source: org_study_id

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