International Research Consortium on Dengue Risk Assessment, Management, and Surveillance

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

7411 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-10-31

Study Completion Date

2016-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Improvements in diagnosis of dengue fever and prediction of which patients will get more severe disease are urgently needed to improve the treatment of patients with dengue. This is very important in places with many people who suffer from dengue but have limited health care resources. This study will enroll patients with fever which may be caused by dengue in 6 countries with high incidence of dengue over two continents (Brazil, Cambodia, El Salvador, Indonesia, Malaysia and Vietnam). All patients will be followed by a doctor with blood tests and exams until they recover. Symptoms and laboratory tests will be followed so that the cause of fever can be determined. For patients who have dengue, the investigators will look for symptoms and tests which indicate more serious disease. This study will help to determine how to identify patients with dengue fever based on symptoms and simple laboratory tests and those who will get more serious disease. It will also help to define a more standardized management of patients with dengue fever.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

New Tools for Predicting Capillary Leak Shock During Dengue Fever

NCT04422782

Dengue Fever Children Adults

UNKNOWN NA

Ability of Bedside Ultrasound to Predict Progression of Severity of Disease in Dengue Fever

NCT02134652

Dengue Disease Progression

WITHDRAWN

Bedside Ultrasound Predicts Progression of Severity of Disease in Dengue Fever

NCT03632486

Dengue Fever

COMPLETED

Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke

NCT05155358

Heat Stroke Early Waking MODS +3 more

NOT_YET_RECRUITING

Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation.

NCT06109532

Hyponatremia Dengue Inflammation

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Improvements in clinical diagnosis of dengue and risk prediction for severe disease are urgently needed to improve overall clinical care, especially in settings with a high case burden where appropriate allocation of limited resources is crucial to outcome. In this work package 10,000 outpatients with undifferentiated fever, consistent with possible dengue, will be recruited within 3 days of fever onset in 6 endemic countries (Brazil, Cambodia, El Salvador, Indonesia, Malaysia and Vietnam), and will be followed daily until full recovery. Clinical features and simple laboratory parameters differentiating dengue from other febrile illness will be identified, and, among those with confirmed dengue, risk factors for progression to more severe disease will be evaluated. As well as contributing to the development of diagnostic and prognostic algorithms the clinical cohort has considerable potential towards standardisation of procedures for dengue management and reporting.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Dengue Fever

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Febrile Patients

Observation of patients with possible dengue fever in the early phase of disease

Observation

Intervention Type OTHER

Clinical follow-up and laboratory investigations.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Observation

Clinical follow-up and laboratory investigations.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* \>= 5 years of age
* fever for less than 72 hours

Exclusion Criteria

* presence of localizing signs suggestive of another diagnosis
* not likely to come back for daily follow-up
* complications or signs of severe disease

Minimum Eligible Age

5 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No