National Early Warning Score and D-dimer to Identify Medical Patients At Low Risk of 30-day Mortality

NCT ID: NCT03108807

Last Updated: 2024-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1700 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-04-24

Study Completion Date

2017-08-19

Brief Summary

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The aim is to determine if the National Early Warning Score combined with plasma D-dimer levels can be used in risk stratification of acutely ill medical patients presenting to a Danish Emergency Department. The investigators wish to identify patients at low risk of mortality within 30 days.

Detailed Description

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Large increases in emergency admissions are raising concerns about whether all admissions are necessary. If there was a fast and reliable system that could be used to determine the risk of all medical patients, many low-risk patients could be safely returned to primary care or outpatient follow-up clinics.

The investigators wish to determine, if the combination of the National Early Warning Score and plasma D-dimer levels can be used to identify patients at low risk of mortality within 30 days in an unselected group of medical patients presenting to a Danish Emergency Department.

This is a prospective observational study that will be performed on adult medical patients referred to the Emergency Department of a Danish hospital to be assessed for possible admission. The study will be performed in the Emergency Department of Hospital of South West Jutland in the region of Southern Denmark.

Conditions

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Medical Patients in the Emergency Department

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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D-dimer test

D-dimer test

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Admission to the Emergency Department of Hospital of South West Jutland
* Requirement of any blood test
* Age 18 years
* Informed consent given

Exclusion Criteria

* Age 18 years
* Informed consent not given
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Southern Denmark

OTHER

Sponsor Role collaborator

Esbjerg Hospital - University Hospital of Southern Denmark

OTHER

Sponsor Role lead

Responsible Party

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Mikkel Brabrand

MD, PhD, clinical associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mikkel Brabrand, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Esbjerg Hospital - University Hospital of Southern Denmark

Locations

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Hospital of South West Jutland

Esbjerg, , Denmark

Site Status

Countries

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Denmark

References

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Nickel CH, Kuster T, Keil C, Messmer AS, Geigy N, Bingisser R. Risk stratification using D-dimers in patients presenting to the emergency department with nonspecific complaints. Eur J Intern Med. 2016 Jun;31:20-4. doi: 10.1016/j.ejim.2016.03.006. Epub 2016 Apr 1.

Reference Type BACKGROUND
PMID: 27053291 (View on PubMed)

Nickel CH, Kellett J, Cooksley T, Bingisser R, Henriksen DP, Brabrand M. Combined use of the National Early Warning Score and D-dimer levels to predict 30-day and 365-day mortality in medical patients. Resuscitation. 2016 Sep;106:49-52. doi: 10.1016/j.resuscitation.2016.06.012. Epub 2016 Jun 20.

Reference Type BACKGROUND
PMID: 27339095 (View on PubMed)

Nickel CH, Kellett J, Nieves Ortega R, Lyngholm L, Wasingya-Kasereka L, Brabrand M. Mobility Identifies Acutely Ill Patients at Low Risk of In-Hospital Mortality: A Prospective Multicenter Study. Chest. 2019 Aug;156(2):316-322. doi: 10.1016/j.chest.2019.04.001. Epub 2019 Apr 11.

Reference Type DERIVED
PMID: 30981722 (View on PubMed)

Other Identifiers

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S-20170005

Identifier Type: -

Identifier Source: org_study_id

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