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Correlation of Clinical and Laboratory Findings and Diuretic Efficacy in Patients With Edematous States in the Emergency Department

NCT ID: NCT03967717

Last Updated: 2023-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

102 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-06-28

Study Completion Date

2022-04-04

Brief Summary

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The aim of the study is the characterization of parameters from medical history, physical examination and diagnostics, which correlate with and could be used to predict diuretic efficacy.

Detailed Description

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This prospective observational study is conducted to identify and further isolate possible predictors for the efficacy of diuretics and to identify potential new predictors.

The study also observes if specific diuretic regimes (e.g. combination of loop diuretics and distal effective diuretics for sequential nephron blockade) have a greater diuretic effect. This is not yet proved.

The data of the study shall to help to determine criteria, allowing to choose an effective diuretic regime in different patient cohorts already at the beginning of therapy and to identify patients at high risk.

Conditions

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Edema

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with edematous states

Patients with edematous states receive standard of care diuretic.

Characterization of parameters of medical history, examination and diagnostics.

Intervention Type OTHER

Patients receive standard of care diuretics. The study only collects data to characterize parameters of medical history, examination and diagnostics.

Interventions

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Characterization of parameters of medical history, examination and diagnostics.

Patients receive standard of care diuretics. The study only collects data to characterize parameters of medical history, examination and diagnostics.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age over 18 years.
* Edema (peripheral and/or pulmonal) of cardiac or renal genesis.

Exclusion Criteria

* Persons who are in a dependency/employment relationship with the investigators.
* Accommodation in an institution by judicial or administrative order.
* Patients in need of ascites puncture and/or thoracentesis on admission day.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Cologne

OTHER

Sponsor Role lead

Responsible Party

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Volker Burst

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Volker Burst, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital of Cologne

Locations

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University Hospital of Cologne

Cologne, , Germany

Site Status

Countries

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Germany

Other Identifiers

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Protocol 1.0

Identifier Type: -

Identifier Source: org_study_id