Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
160 participants
OBSERVATIONAL
2017-05-07
2018-07-09
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Only few studies exist on severe leptospirosis and none major multicentre on leptospirosis in intensive care units in Europe. The investigators conduct a retrospective multi centric study in metropolitan France in order to identify the characteristic, the treatments and the prognostic factors associated with mortality of sever leptospirosis.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Leptospirosis Registry - LeptoScope
NCT04288674
New Tools for Predicting Capillary Leak Shock During Dengue Fever
NCT04422782
PAthwAy of Dyspneic patIent in Emergency in France
NCT06509854
The Clinical and Hemodynamic Course of Cardiogenic Shocks Hospitalized in Critical Care
NCT05752383
PAthwAy of Dyspneic patIent in Emergency in the North-east Region (North-East PArADIsE)
NCT06235008
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Only few studies exist on severe leptospirosis and none major multicentre on leptospirosis in intensive care units in Europe. Therefore, the investigators have decided to carry out this studies. The investigators conduct a retrospective multi centric study in metropolitan France in order to identify the characteristic, the treatments and the prognostic factors associated with mortality of sever leptospirosis.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
COHORT
RETROSPECTIVE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Patient admitted in the ICU for leptospirosis
Patient admitted in the ICU for leptospirosis None intervention was performed according to retrospective design
No interventions assigned to this group
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Leptospirosis confirmed with one laboratory test (MAT, ELISA, PCR, direct examination)
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Nantes University Hospital
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Jean Reignier, MD, PhD
Role: STUDY_DIRECTOR
Nantes University Hospital
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
CHU Amiens-Picardie
Amiens, , France
CHU Angers
Angers, , France
CH Angoulème
Angoulême, , France
CH Annecy
Annecy, , France
CH Avignon
Avignon, , France
hopital saint Leon, CH de la Cote Basque
Bayonne, , France
CHU Besançon
Besançon, , France
CH Fleyriat
Bourg-en-Bresse, , France
CHU de Caen
Caen, , France
CH Cahors
Cahors, , France
CH Chartres
Chartres, , France
CH Cholet
Cholet, , France
CHD de la Vendée
La Roche-sur-Yon, , France
Hopital Saint Louis
La Rochelle, , France
CH Le Mans
Le Mans, , France
CH Lens
Lens, , France
CHU de Lille
Lille, , France
Hopital Edouard Herriot, Hospices civils de Lyon
Lyon, , France
GHR MSA
Mulhouse, , France
CHRU de Nancy
Nancy, , France
CH Niort
Niort, , France
CHU Bicetre APHP
Paris, , France
CHU Cochin APHP
Paris, , France
CHU Henri Mondor
Paris, , France
CHU Saint Louis, APHP
Paris, , France
CH Périgueux
Périgueux, , France
CH René-Dubost
Pontoise, , France
CHU Rennes
Rennes, , France
CHU Rouen
Rouen, , France
CH Saint Brieuc
Saint-Brieuc, , France
CH Saint Nazaire
Saint-Nazaire, , France
CH Saint Malo
St-Malo, , France
CHRU Bretonneau
Tours, , France
CH Valenciennes
Valenciennes, , France
CH Vannes
Vannes, , France
Hopital André Mignot
Versailles, , France
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Haake DA, Levett PN. Leptospirosis in humans. Curr Top Microbiol Immunol. 2015;387:65-97. doi: 10.1007/978-3-662-45059-8_5.
Picardeau M. Virulence of the zoonotic agent of leptospirosis: still terra incognita? Nat Rev Microbiol. 2017 May;15(5):297-307. doi: 10.1038/nrmicro.2017.5. Epub 2017 Mar 6.
Delmas B, Jabot J, Chanareille P, Ferdynus C, Allyn J, Allou N, Raffray L, Gauzere BA, Martinet O, Vandroux D. Leptospirosis in ICU: A Retrospective Study of 134 Consecutive Admissions. Crit Care Med. 2018 Jan;46(1):93-99. doi: 10.1097/CCM.0000000000002825.
Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Negl Trop Dis. 2015 Sep 17;9(9):e0003898. doi: 10.1371/journal.pntd.0003898. eCollection 2015.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
LEPTOREA
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.