Acute Liver Injury in Patients With Pneumonia

NCT ID: NCT06103981

Last Updated: 2023-10-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

176 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-01

Study Completion Date

2025-03-10

Brief Summary

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Acute liver injury (ALI) is defined as an acute derangement in liver function tests associated with liver-related coagulopathy, in the absence of underlying chronic liver disease.

A subset progress to acute liver failure ,Acute liver failure represent a more severe liver injury results in hepatic encephalopathy

Detailed Description

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Acute liver injury is associated with a spectrum of haemostatic changes, including thrombocytopenia and reduced platelet function, reduced plasma levels of many coagulation factors such as factor (F)VII and increased levels of FVIII .

Pneumonia is an acute inflammation of the lower respiratory tract. Lower respiratory tract infection is a major cause of mortality worldwide .Pneumonia is most common at the extremes of life.

In adults, pneumonia can be broadly classified, on the basis of chest radiographic appearance, into lobar pneumonia, bronchopneumonia and pneumonia producing an interstitial pattern.

There is lack of data regarding outcome and hospital stay in patients with pneumonia who develop acute liver injury.

Conditions

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Acute Liver Injury Pneumonia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Group A

About 88 patients having pneumonia and developed acute liver injury That need observation of the outcome and hospital stay to evaluate acute liver injury impact

Acute Liver Injury

Intervention Type OTHER

To evaluate the impact of acute liver injury in patients with pneumonia on hospital stay and outcome.

Group B

About 88 patients having pneumonia but did not develop acute liver injury that need observation of the outcome and hospital stay

Acute Liver Injury

Intervention Type OTHER

To evaluate the impact of acute liver injury in patients with pneumonia on hospital stay and outcome.

Interventions

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Acute Liver Injury

To evaluate the impact of acute liver injury in patients with pneumonia on hospital stay and outcome.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Patients with pneumonia that developed Acute Liver Injury
2. Covid 19 pneumonia
3. Patients With acute liver injury only.

Exclusion Criteria

1. Cancer
2. Immunocompromised patients i.e HIV patients and patients who take immunosuppressive medications.
3. Patients who younger than 18 yrs old
4. pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

68 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Beshoy Yousef Boles Abdelmalak

Resident

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Zain Elabdeen Ahmed, Professor

Role: STUDY_CHAIR

Assuit Faculty of Medicine

Locations

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Faculty Of Medicine

Asyut, , Egypt

Site Status

Countries

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Egypt

Central Contacts

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Beshoy Yousef, MSc

Role: CONTACT

01114761284

Zain Elabdeen Ahmed, Professor

Role: CONTACT

01115596820

Other Identifiers

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Acute Liver Injury

Identifier Type: -

Identifier Source: org_study_id

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