Pattern of Acute on Chronic Liver Failure in Patient With HCV Related Chronic Liver Disease

NCT ID: NCT03456518

Last Updated: 2020-01-23

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-11-01
• Study Completion Date: 2019-11-30

Brief Summary

The concept of acute-on-chronic liver failure (ACLF) was introduced by Jalan and Williams in 2002 to describe the acute deterioration in liver function over 2 to 4 weeks in a patient with well-compensated cirrhosis associated with a precipitating event (hepatotoxic: superimposed hepatitis viral infection, drug-induced liver injury, hepatotoxins, or excessive alcohol consumption; extra hepatic: variceal bleeding or sepsis), leading to severe deterioration in clinical status with jaundice and hepatic encephalopathy and/or HRS. Following this concept, several proposals for the diagnostic criteria of ACLF have been suggested.

Detailed Description

There may be regional differences in etiology, pathogenesis, and natural course of ACLF, which may in turn influence the overall outcome of this syndrome. So, proper diagnosis of ACLF and its precipitating factors in our locality enable us for proper management of these cases and dealing with these precipitating factors to be avoided later on in patients with liver cirrhosis

Aim of the work:

To identify the pattern of acute on chronic liver cell failure (ACLF) within 28 days including prevalence, percipitating factors, and outcome.

Patients and methods

Type of the study: Prospective hospital based study

Site of the study: Tropical Medicine and Gastroenterology Department, Al-Rajhi University Hospital, Assiut University Hospitals, Assiut, Egypt. Written consent will be obtained from all the participants or their relatives before enrollment.

Conditions

Acute-On-Chronic Liver Failure

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Adult Patients with HCV related CLD based on clinical, biochemical and imaging evidence., with or without prior decompensation.
• Patients diagnosed to have ACLIF at any grade (1-3)

Exclusion Criteria

• Acute liver failure without evidence of chronic liver disease.
• Other etiology of chronic liver disease
• Patients diagnosed with no ACLIF No ACLF
• This category includes patients who either:

• Do not have any organ failure
• Have a single organ failure that does not involve the kidney with a serum creatinine level of <1.5 mg per dl and no hepatic encephalopathy
• Have a single brain failure with a serum creatinine level of <1.5 mg per dl
• Patients refuse to participate.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Tasneem Khaled

resident doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Mohammed Medhat

Role: STUDY_DIRECTOR

Al-Arajhy Liver Hospital, Assiut University

Locations

Al-Rajhi Liver Hospital, Assiut University

Asyut, , Egypt

Al-Rajhi liver hospital ,Assiut university

Asyut, , Egypt

Countries

Egypt

References

Gines P, Quintero E, Arroyo V, Teres J, Bruguera M, Rimola A, Caballeria J, Rodes J, Rozman C. Compensated cirrhosis: natural history and prognostic factors. Hepatology. 1987 Jan-Feb;7(1):122-8. doi: 10.1002/hep.1840070124.

Reference Type: BACKGROUND

PMID: 3804191 (View on PubMed)

Other Identifiers

POACLIFWHCV LC

Identifier Type: -

Identifier Source: org_study_id