Pattern and Short Term Outcomes of Renal Affection in Patients With Liver Cirrhosis in Al-Rajhi Liver Hospital

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

290 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-01

Study Completion Date

2025-12-31

Brief Summary

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* To characterize the pattern and the prevalence of renal affection among liver cirrhosis patients.
* To evaluate the short-term outcomes of those patients.

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Detailed Description

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Liver cirrhosis is a chronic liver disease characterized by significant scarring and dysfunction. One of its common complications is renal affection , which can significantly impact patient outcomes .

Aetiology of AKI can be categorized into three main types. These are prerenal (results from decreased renal perfusion), intrinsic renal (acute tubular necrosis), and postrenal AKI. In patients on admission, acute tubular necrosis is a common type of intrinsic AKI .

The development of portal hypertension in patients with liver cirrhosis leading to a reduction in systemic vascular resistance as a result of primary arterial vasodilation in the splanchnic circulation is the primary cause of AKI in cirrhotics. This mechanism primarily leads to hepatorenal syndrome. In addition, the underlying causes of liver cirrhosis can be the cause of intrinsic renal disease .

Early identification and management of AKI may improve outcomes. AKI in patients with liver cirrhosis in Egypt and their impact on inpatient mortality are largely unknown. This study was aimed at determining the prevalence, precipitating factors, predictors, and in-hospital mortality of AKI in patients with liver cirrhosis admitted at Al-Rajhi liver hospital at Egypt .

Conditions

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Liver Cirrhosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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liver cirrhosis admitted to Al-Rajhi liver hospital

observation of renal affection in patients known to have liver cirrhosis

observation of renal affection in patients with liver cirrhosis

Intervention Type OTHER

* CBC
* Liver function test
* kidney function test (serum creatinine, BUN, eGFR (EPI equation and MDRD equation) ,
* Prothrombin time and concentration, INR,
* Serum electrolytes
* Urine analysis.

Interventions

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observation of renal affection in patients with liver cirrhosis

* CBC
* Liver function test
* kidney function test (serum creatinine, BUN, eGFR (EPI equation and MDRD equation) ,
* Prothrombin time and concentration, INR,
* Serum electrolytes
* Urine analysis.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with liver cirrhosis admitted to the department .

Exclusion Criteria

1. Patients with known preexisting chronic kidney disease according to KDIGO and EASL 2018 definitions ( defined as functional GFR \<60 ml/min per 1.73 m 2 for ≥3 months or structural kidney damage for ≥3 months ).
2. Patient refusal to give informed consent ( or his first degree relatives in case of disturbed conscious level).

Eligible Sex

ALL

Accepts Healthy Volunteers

No