Correlation of Platelets Count With Endoscopic Findings in a Cohort of Egyptian Patients With Liver Cirrhosis

NCT ID: NCT02621372

Last Updated: 2017-06-20

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-01-31
• Study Completion Date: 2019-10-31

Brief Summary

Portal hypertension is a common complication of liver cirrhosis that can lead to development of esophageal varices (EV). They are abnormally dilated veins within the wall of the esophagus that lead to haemorrhage (1). Majority of patients with cirrhosis will develop EV at some point, and about third of these patients will have at least one bleeding episode because of rupture of a varix . For this reason, screening endoscopy for detection of the presence of EV should be part of the diagnostic work-up in patients with cirrhosis. This is a very important preventive step for identification of those patients with variceal bleeding risk and furthermore, identification of patients in urgent need for prophylactic treatment.

All guidelines stress on screening endoscopy for early detection of EV in cirrhotic patients with portal hypertension. However this approach is limited by its invasiveness and cost effectiveness issues of screening endoscopy .

Detailed Description

Recent research has focused on the use of noninvasive methods to detect patients with the intention of avoiding endoscopy in low-risk cases . Thrombocytopenia (platelet count < 150,000/μl) is a common complication in patients of chronic liver disease (CLD) . So, the investigators in this research formulated this study to determine whether platelet count can predict the presence of EV or varices which need prophylactic therapy (medium or large size EV) in a cohort of Egyptian patients with liver cirrhosis and can identify patients with the intention of avoiding endoscopy in low-risk cases.

Conditions

Portal Hypertension

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: OTHER

Interventions

platelet count

Correlation of esophageal varices with platelet count

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Diagnosis of cirrhosis based on history, physical examination, laboratory tests, ultrasound scans and liver biopsy in some occasion.

Exclusion Criteria

• Hepatocellular carcinoma.
• Portal vein thrombosis.
• Parenteral drug addiction.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tanta University

OTHER

Sponsor Role: collaborator

Sherief Abd-Elsalam

OTHER

Sponsor Role: lead

Responsible Party

Sherief Abd-Elsalam

Hepatology and gastroenterology dept., tanta university, M.D., Principle investigator

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Sherief Abd-Elsalam

Role: PRINCIPAL_INVESTIGATOR

Tanta university hospital

Locations

Tropical medicine dept.-Tanta university hospital

Tanta, , Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Sherief M Abd-Elsalam, lecturer

Role: CONTACT

sherif_tropical@yahoo.com

00201095159522

Facility Contacts

Sherief Abd-Elsalam

Role: primary

Sherif_tropical@yahoo.com

Other Identifiers

non invasive diagnosis of EV

Identifier Type: -

Identifier Source: org_study_id