Hepatic Manifestations and Effect of Long COVID-19 on Patients With Chronic Liver Disease

NCT ID: NCT04998214

Last Updated: 2023-02-06

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 65 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-08-19
• Study Completion Date: 2023-04-30

Brief Summary

To measure the frequency of persistent liver dysfunction (raised liver enzymes, serum albumin, prothrombin time, etc) in recovered COVID -19 patients.

To compare the hepatic manifestations in post COVID -19 patients with and without liver disease

Detailed Description

The digestive tract, particularly the liver, has recently been reported to be affected by SARS-CoV-2. Although abnormal liver enzymes were regularly described as an extra-pulmonary clinical feature, and almost one half of patients experienced grades of hepatic injury. liver damage in patients with SARS infections was primarily manifested in the mild and moderate elevation of alanine and/or aspartate aminotransferases (ALT and AST) with some degree of hypoalbuminemia and hyperbilirubinemia during the early stage of the illness.

Conditions

COVID-19

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

control group non cirrhotic

compare liver function 1m after COVID-19 and that at beginning of infection

liver function , prothrombin time , INR , US .

Intervention Type: DIAGNOSTIC_TEST

analytic

cirrhotic patients

compare liver function 1m after COVID-19 and that at beginning of infection

liver function , prothrombin time , INR , US .

Intervention Type: DIAGNOSTIC_TEST

analytic

Interventions

liver function , prothrombin time , INR , US .

analytic

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Patients previously diagnosed by COVID 19 eg : PCR and / or HRCT chest, lab of more than 1 month duration.

Exclusion Criteria

• Patients less than 18 y.
• Patients with acute COVID 19.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Huda Mokhtar Salim

clinical professor : Mohammed El _Taher Abdel_Rahman .

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Khaled Abu Bakr

Role: STUDY_DIRECTOR

Assiut University

Locations

Faculty of Medicine

Asyut, , Egypt

Countries

Egypt

References

Ye ZW, Yuan S, Yuen KS, Fung SY, Chan CP, Jin DY. Zoonotic origins of human coronaviruses. Int J Biol Sci. 2020 Mar 15;16(10):1686-1697. doi: 10.7150/ijbs.45472. eCollection 2020.

Reference Type: BACKGROUND

PMID: 32226286 (View on PubMed)

Fung SY, Yuen KS, Ye ZW, Chan CP, Jin DY. A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses. Emerg Microbes Infect. 2020 Mar 14;9(1):558-570. doi: 10.1080/22221751.2020.1736644. eCollection 2020.

Reference Type: BACKGROUND

PMID: 32172672 (View on PubMed)

Sultan S, Lim JK, Altayar O, Davitkov P, Feuerstein JD, Siddique SM, Falck-Ytter Y, El-Serag HB; AGA Institute. Electronic address: ewilson@gastro.org. AGA Rapid Recommendations for Gastrointestinal Procedures During the COVID-19 Pandemic. Gastroenterology. 2020 Aug;159(2):739-758.e4. doi: 10.1053/j.gastro.2020.03.072. Epub 2020 Apr 1. No abstract available.

Reference Type: BACKGROUND

PMID: 32247018 (View on PubMed)

Other Identifiers

liver in COVID-19

Identifier Type: -

Identifier Source: org_study_id