Platelets to Lymphocytes Ratio and Monocytes to Lymphocytes Ratio as Predictors of Response to Treatment in Cirrhotic Patients With Spontaneous Bacterial Peritonitis.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-04-19

Study Completion Date

2024-04-30

Brief Summary

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Spontaneous bacterial peritonitis (SBP) is a serious complication of ascites that can lead to death and can be described as an acute infection of ascites without any certain source of infection SBP is considered the most common infection in cirrhotic patients with ascites. SBP is diagnosed by the presence of ≥250 polymorphonuclear leukocyte (PMNL)/mm3 in the ascetic fluid in absence of surgical and treatable causes of intra-abdominal infections .

SBP has many pictures of clinical presentation SBP can be asymptomatic and patients pass unnoticed or can discovered accidentally may have local symptoms and signs of peritonitis such as abdominal pain, and tachypnea or may present with signs of deteriorated liver function in form of gastrointestinal bleeding, shock and renal failure An increasing amount of studies have demonstrated that peripheral blood neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR) are indicators of systematic inflammatory response and are widely investigated as useful predictors of the clinical outcomes in various diseases .

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Detailed Description

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Conditions

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Cirrhotic Patients With Spontaneous Bacterial Peritonitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Cirrhotic Patients with Spontaneous Bacterial Peritonitis

ascetic fluid study

Intervention Type DIAGNOSTIC_TEST

ascetic fluid study parameter in diagnosis of spontaneous bacterial peritpnitis

patient liver cirrhosis (child B,C)

No interventions assigned to this group

normal individuals

No interventions assigned to this group

Interventions

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ascetic fluid study

ascetic fluid study parameter in diagnosis of spontaneous bacterial peritpnitis

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Cirrhotic patient with ascites.
* Un treated SBP

Exclusion Criteria

* Ascites without cirrhosis (malignant ascites, chylous ascites, etc…).
* Tuberculous peritonitis.
* Secondary bacterial peritonitis due to any surgical cause.
* Sepsis rather than SBP.
* Patients with unrelated infections e.g. skin, chest infection, etc.
* Patients started treatment of SBP.
* Patients on prophylactic antibiotics for recurrent SBP prevention .
* Patients declining to provide informed consent.
* Patients with hepatocellular carcinoma on top of cirrhosis.
* Patients with other malignancy or any immunological disease

Minimum Eligible Age

15 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Mohamed Hamed Mohamed

Platelets to Lymphocytes Ratio and Monocytes to Lymphocytes Ratio as Predictors of Response to Treatment in Cirrhotic Patients with Spontaneous Bacterial Peritonitis

Responsibility Role PRINCIPAL_INVESTIGATOR