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Spontaneous Bacterial Peritonitis: Incidence, Risk Factors and Outcome

NCT ID: NCT00490217

Last Updated: 2007-06-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

240 participants

Study Classification

OBSERVATIONAL

Study Start Date

1993-12-31

Study Completion Date

2007-03-31

Brief Summary

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Spontaneous bacterial peritonitis (SBP) is a severe complication of ascites in cirrhotic patients. Under clinical experience, this condition seems to be more uncommon in Finland. The aim of this study was to measure the incidence of SBP in consecutive patients with ascites requiring hospitalization in a Finnish University Hospital.

Detailed Description

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Spontaneous bacterial peritonitis (SBP) is a complication of liver cirrhosis with high mortality and low survival rates. The incidence of SBP is reported to range from 11-35% in patients with ascites requiring hospitalization. Under clinical experience, the incidence of SBP in Finland seems to be lower than reported elsewhere. Alcohol is the dominant etiologic factor of liver cirrhosis in Finland (90%), which might be a factor affecting the incidence of SBP. The aim of this study is to measure the incidence of SBP in Finland. We included consecutive patients who underwent diagnostic paracentesis for ascites in Tampere University Hospital during 2/1994 - 12/1998 and 1/2005 - 3/2007. Spontaneous bacterial peritonitis was diagnosed when the ascitic fluid contained over 250 polymorphonuclear cells / mm\^3 regardless of culture and with no evidence of intra-abdominal source of infection e.g. an abscess or a perforation.

Conditions

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Spontaneous Bacterial Peritonitis Primary Peritonitis Ascites

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnostic paracentesis performed during the study period
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tampere University

OTHER

Sponsor Role lead

Principal Investigators

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Jahangir A Khan, MS

Role: PRINCIPAL_INVESTIGATOR

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital

Pekka Collin, MD

Role: STUDY_DIRECTOR

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital

Pekka Pikkarainen, MD

Role: STUDY_DIRECTOR

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital

Locations

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Tampere University Hospital

Tampere, Pirkanmaa, Finland

Site Status

Countries

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Finland

Other Identifiers

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R065585-1

Identifier Type: -

Identifier Source: org_study_id