Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool
NCT ID: NCT06088758
Last Updated: 2025-11-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
200 participants
INTERVENTIONAL
2024-02-28
2027-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Liver Transplantation with Steatotic Liver
Graft will be selected if 30-60% macrosteatosis and transplanted into liver transplant recipient with MELD of 15-25.
Normothermic machine perfusion (NMP) of steatotic liver
Steatotic liver grafts that are selected will be run on NMP to assess quality of graft and determine whether it meets criteria for transplantation
Interventions
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Normothermic machine perfusion (NMP) of steatotic liver
Steatotic liver grafts that are selected will be run on NMP to assess quality of graft and determine whether it meets criteria for transplantation
Eligibility Criteria
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Inclusion Criteria
* Listed for liver transplantation at MGH
* Calculated MELD-Na score \<= 25
* Able to consent
Exclusion Criteria
* Cardiac or pulmonary disease
* Prior liver transplant
* Requiring pressors at the time of liver offer
* MELD\<15 and asymptomatic from liver disease
18 Years
80 Years
ALL
No
Sponsors
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Massachusetts General Hospital
OTHER
Responsible Party
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Heidi Yeh
Principal Investigator
Locations
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Massachusetts General Brigham
Boston, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2023P002561
Identifier Type: -
Identifier Source: org_study_id
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