cSEMS vs. NEPS in Stricture of Biliary Anastomosis After Liver Transplantation

NCT ID: NCT01393067

Last Updated: 2016-08-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2015-03-31

Brief Summary

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Stenosis at the bilio-biliary anastomosis occurs in up to 30% of patients after orthotopic liver transplantation. This study compares endoscopic treatment with implantation of multiple plastic endoprostheses vs. use of a removable, covered self-expandable metal stent (cSEMS).

Detailed Description

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This is a multi-center randomised trial.

Conditions

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Stenosis of the Bilio-biliary Anastomosis After Orthotopic Liver Transplantation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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study group NEPS

implantation of multiple non-expandable plastic stents

Group Type ACTIVE_COMPARATOR

Non-expandable plastic stent (plastic endoprosthesis)

Intervention Type DEVICE

plastic stent (plastic endoprosthesis)

group cSEMS

implantation of a self-expandable metal stent (cSEMS)

Group Type ACTIVE_COMPARATOR

Covered self-expandable metal stent (cSEMS)

Intervention Type DEVICE

Removable, covered self-expandable metal stent (cSEMS)

Interventions

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Non-expandable plastic stent (plastic endoprosthesis)

plastic stent (plastic endoprosthesis)

Intervention Type DEVICE

Covered self-expandable metal stent (cSEMS)

Removable, covered self-expandable metal stent (cSEMS)

Intervention Type DEVICE

Other Intervention Names

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OptiMed, Boston Scientifiv, MTW Niti-S biliary stent, fully covered

Eligibility Criteria

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Inclusion Criteria

* post-OLT stenosis of the bilio-biliary anastomotic

Exclusion Criteria

* non-anastomotic stricture
* stent implatation technically not feasible
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Johann Wolfgang Goethe University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jorg Albert

Johann Wolfgang Goethe University Hospitals.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jörg Albert, MD

Role: PRINCIPAL_INVESTIGATOR

Johann Wolfgang Goethe University Hospital and Clinics Department of Internal Medicine I

Locations

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University of Helsinki

Helsinki, , Finland

Site Status

Klinik für Gastroenterologie und Hepatologie, Medizinische Hochschule Essen

Essen, , Germany

Site Status

Department of Internal Medicine I

Frankfurt, , Germany

Site Status

University of Milano

Milan, , Italy

Site Status

Countries

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Finland Germany Italy

References

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Phillips MS, Bonatti H, Sauer BG, Smith L, Javaid M, Kahaleh M, Schmitt T. Elevated stricture rate following the use of fully covered self-expandable metal biliary stents for biliary leaks following liver transplantation. Endoscopy. 2011 Jun;43(6):512-7. doi: 10.1055/s-0030-1256389. Epub 2011 May 26.

Reference Type BACKGROUND
PMID: 21618151 (View on PubMed)

Tal AO, Finkelmeier F, Filmann N, Kylanpaa L, Udd M, Parzanese I, Cantu P, Dechene A, Penndorf V, Schnitzbauer A, Friedrich-Rust M, Zeuzem S, Albert JG. Multiple plastic stents versus covered metal stent for treatment of anastomotic biliary strictures after liver transplantation: a prospective, randomized, multicenter trial. Gastrointest Endosc. 2017 Dec;86(6):1038-1045. doi: 10.1016/j.gie.2017.03.009. Epub 2017 Mar 14.

Reference Type DERIVED
PMID: 28302527 (View on PubMed)

Kahaleh M, Behm B, Clarke BW, Brock A, Shami VM, De La Rue SA, Sundaram V, Tokar J, Adams RB, Yeaton P. Temporary placement of covered self-expandable metal stents in benign biliary strictures: a new paradigm? (with video). Gastrointest Endosc. 2008 Mar;67(3):446-54. doi: 10.1016/j.gie.2007.06.057.

Reference Type BACKGROUND
PMID: 18294506 (View on PubMed)

Wang AY, Ellen K, Berg CL, Schmitt TM, Kahaleh M. Fully covered self-expandable metallic stents in the management of complex biliary leaks: preliminary data - a case series. Endoscopy. 2009 Sep;41(9):781-6. doi: 10.1055/s-0029-1215050. Epub 2009 Aug 19.

Reference Type BACKGROUND
PMID: 19693751 (View on PubMed)

Other Identifiers

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148/10

Identifier Type: -

Identifier Source: org_study_id

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