Testing Regional anesthesia Techniques For Up And Early Discharge Following Knee arthroplasty

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE4

Total Enrollment

226 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-01-01

Study Completion Date

2027-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To assess feasibility of a a trial investigation postoperative patient-reported quality of recovery after total knee arthroplasty (TKA) with periarticular joint injection (PAI) ± single shot adductor canal block with or without adductor canal catheter infusion.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effectiveness of a Femoral Block Following Total Knee Arthroplasty (TKA)

NCT00659087

Total Knee Arthroplasty

COMPLETED PHASE4

Evaluation of a Fast-track Knee Arthroplasty Concept

NCT03114306

Knee Arthropathy Postoperative Pain Postoperative Complications

COMPLETED NA

Enhanced Recovery After Surgery (ERAS) Total Knee Replacement (TKR) With a Transitional Pain Service

NCT03747146

Anesthesia

RECRUITING NA

Feasibility Study of Peripheral Venous Cannulation Pain in Predicting Acute Pain After Total Knee Arthroplasty

NCT06002724

Venous Cannulation Pain Total Knee Arthroplasty Movement-evoked Pain +1 more

UNKNOWN

Intraarticular Analgesia After Total Knee Arthroplasty, a Randomised Study

NCT00269529

Arthroplasty, Replacement, Knee

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Knee osteoarthritis (KOA) is a leading cause of chronic knee pain and disability, with a lifetime prevalence of 45%. Treatment for symptomatic KOA includes physical therapy, oral anti-inflammatory medications and intra-articular steroid injections, with total knee arthroplasty (TKA) (or knee replacement) as the definitive treatment. Acute postoperative pain is common after TKA, leading to increased opioid consumption and increased hospital length of stay. Pain control following TKA has been investigated with interventions such as intrathecal morphine, nerve blocks, and periarticular joint injection (PAI). PAI and adductor canal block are well-established techniques used both in combination or in isolation in the management of postoperative pain for patients undergoing TKA. The aim of this study is to assess postoperative patient-reported quality of recovery after TKA with PAI and single shot adductor canal block with or without adductor canal catheter infusion.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Arthroplasty, Replacement, Knee

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized control trial

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Pharmacy will have access to the randomization scheme. All other members of the study team are blinded.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

cACB active

Periarticular joint injection (medication) + single shot adductor canal block (medication) + adductor canal catheter infusion (medication)

Group Type EXPERIMENTAL

Ropivacaine

Intervention Type DRUG

800 mg ropivacaine in continuous infusion adductor canal block (400 mL total volume)

cACB sham

Periarticular joint injection (medication) + single shot adductor canal block (medication) + adductor canal catheter infusion (normal saline)

Group Type PLACEBO_COMPARATOR

Normal saline

Intervention Type DRUG

400 mL normal saline in continuous infusion adductor canal block (400 mL total volume)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Ropivacaine

800 mg ropivacaine in continuous infusion adductor canal block (400 mL total volume)

Intervention Type DRUG

Normal saline

400 mL normal saline in continuous infusion adductor canal block (400 mL total volume)

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* All adult patients presenting for a primary TKA.

Exclusion Criteria

* Age \<18 years;
* Body mass index ≥45 kg/m2;
* Weight \<80 kg;
* Deemed unsuitable for regional anesthesia;
* Planned general anesthesia;
* Hepatic insufficiency/Intolerance to acetaminophen;
* Renal insufficiency (defined by estimated glomerular filtration rate \<60 mL/min/1.73 m2);
* Chronic opioid use (individuals requiring the equivalent of 1 mg or more of intravenous morphine, or 3 mg or more of oral morphine per hour for greater than 1 month);
* Allergy or intolerance to study medications (listed under 'Spinal and Adductor Canal Block') or trial medications listed in "Postoperative" section and "standard prescription"
* Clinical Frailty Scale score ≥4;

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No