Intraarticular Analgesia After Total Knee Arthroplasty, a Randomised Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-02-28

Study Completion Date

2006-03-31

Brief Summary

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The study aims to compare two different kinds of pain treatment after total knee replacement (operation with artificial knee joint): 1) a large local injection in and around the knee, supplemented with injection the day after, or 2) the department's conventional pain treatment consisting of continuous nerve block in the groin.

Detailed Description

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Postoperative pain after total knee arthroplasty is moderate to severe and can be difficult to treat. The current use of femoral nerve block by ropivacain pump for 48 hours provides considerable analgesia, but patients often experience slight motor block, inhibiting rehabilitation, and pain in the posterior part of the knee, innervated by the sciatic nerve. This study compares femoral nerve block to a new technique, where ropivacaine, ketorolac and adrenalin is used to infiltrate the tissue in and around the knee joint during surgery, and is injected by an intraarticular catheter at 10 pm on the day of surgery and again at 10 am the day after. Data of pain scores, analgesia consumption, adverse effects and mobilisation is collected for the first four postoperative days.

Conditions

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Arthroplasty, Replacement, Knee

Keywords

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postoperative pain knee arthroplasty analgesia infiltration femoral nerve block

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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femoral nerve block

Intervention Type PROCEDURE

knee infiltration and injection via catheter

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients planned for primary total knee arthroplasty due to primary arthrosis

Exclusion Criteria

* Patients unable to provide informed consent
* patients with contraindications for spinal anesthesia
* patients with known hypersensitivity towards the used drugs
* patients with severe chronic neurogenic pain or sensitivity disorders in the leg to be operated
* patients who have undergone major bone surgery in the knee to be operated

Minimum Eligible Age

0 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Else Tønnesen, Professor

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark

Kjeld Søballe, Professor

Role: PRINCIPAL_INVESTIGATOR

Orthopedic Center, Aarhus University Hospital, Aarhus, Denmark

Locations

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Aarhus Hospital, Tage Hansens Gade

Aarhus, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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20050003

Identifier Type: -

Identifier Source: org_study_id