Evaluation of Platelet Rich Plasma in Skin Graft Take for Patients With Post Burn Raw Areas
NCT ID: NCT05996614
Last Updated: 2023-08-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
NA
40 participants
INTERVENTIONAL
2023-10-01
2025-02-28
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
2. To evaluate the effect of PRP on wound healing on skin graft donor site.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Comparative Study Between Fat Injection And Platelet Rich Plasma In Post Burn Facial Scar
NCT04557514
Non-cultured Autologous Keratinocyte Suspension Versus Traditional Split Skin Graft for Burn Wounds Treatment
NCT03675568
Autologous Keratinocyte Suspension Versus Adipose-Derived Stem Cell-Keratinocyte Suspension for Post-Burn Raw Area
NCT03686449
Use of Autologous Platelet-Rich Plasma to Treat Hypertrophic Burn Scars
NCT03935594
The Effect of Platelet Rich Plasma on Pain at Skin Graft Donor Sites
NCT03937765
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The time to complete wound healing ranged from 2 to 75 days. Factors that significantly affected time to complete wound healing were graft loss by seroma, presence of hypergranulation tissue, premorbid conditions, and total body surface area burned.
Generally, skin graft undertakes three steps for healing: anchorage, inosculation, and maturation. Haematoma, shearing, and infection on recipient sites of skin graft can reduce skin graft take, and even lead to skin graft loss.
Platelet-rich plasma (PRP) is an autologous blood-derived biomaterial that is enriched with a 2- to 6-fold concentration of platelets in comparison to normal human platelet concentration. Multiple growth factors and bioactive proteins are stored in α-granules of platelets. These growth factors can promote proliferation of endothelial cells, epithelial cells as well as fibroblasts, and increase angiogenesis. The potential clinical application of PRP in skin graft might rely on its haemostasis, adhesive, antibacterial and healing properties.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
group with PRP
Group of patients with post burn raw areas treated with application of platelet rich plasma
PRP in skin grafts
topical application of platelet rich plasma before resurfacing with STSG in Post burn raw areas
group without PRP
Group of patients with post burn raw areas treated with conventional methods
conventional methods in skin grafts
fixation of the graft with stitches and staplers
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
PRP in skin grafts
topical application of platelet rich plasma before resurfacing with STSG in Post burn raw areas
conventional methods in skin grafts
fixation of the graft with stitches and staplers
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
2. Post burn Raw area less than 10 % of total body surface area .
3. Selected donor sites.
Exclusion Criteria
2. Patients with bleeding tendency.
3. Patients with comorbidities(diabetes, malignancy,..etc)
15 Years
60 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Assiut University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Ibrahim Ragab Ibrahim ali
principal investigator
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Mostafa Elsonbaty, prof
Role: STUDY_CHAIR
Assiut University
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
References
Explore related publications, articles, or registry entries linked to this study.
Garcia-Sanchez JM, Mirabet Lis V, Ruiz-Valls A, Perez-Plaza A, Sepulveda Sanchis P, Perez-Del-Caz MD. Platelet rich plasma and plasma rich in growth factors for split-thickness skin graft donor site treatment in the burn patient setting: A randomized clinical trial. Burns. 2022 Nov;48(7):1662-1670. doi: 10.1016/j.burns.2021.10.001. Epub 2021 Oct 22.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
PRP in skin grafts
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.