Significance of Platelet Indices and Ratios in Different Degrees of Burn

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

333 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-10-10

Study Completion Date

2025-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Study the correlation between the platelet indices and different degrees of burn Study the correlation between the platelet ratios and different degrees of burn.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Evaluation of Platelet Rich Plasma in Skin Graft Take for Patients With Post Burn Raw Areas

NCT05996614

Skin Burn

UNKNOWN NA

Chronology of Occult and Gross Coagulopathy in Burn Patients

NCT01638481

Thermal Burns

COMPLETED

Soluble Factors in the Serum of Severely Burned Patients

NCT02549079

Burn Patients

COMPLETED

Effect of Enteral Albumin on Healing of Superficial Partial Thickness Fresh Flame Burns of Adults

NCT03709069

Partial-thickness Burn

UNKNOWN NA

Identification and Validation of Biomarkers for Infections in Burns

NCT02457663

Burns Involving 20% or More of Body Surface

TERMINATED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Burns are a major traumatic pathology characterized by tissue destruction and cellular degradation resulted by energy transfer and mainly affect skin, which serve as significant cause of morbidity and mortality. burns are classified as first,second and third degree depending on how deep and severe they penetrate the skin surface.

Platelets play important role in primary homeostasis, thrombosis, inflammation and tissue regulation in the processes of wound healing. Platelets can contact exposed collagen and extra cellular matrix and releasing clotting factors to achieve homeostasis as well as essential growth factors and cytokines to repair the wound.In clinical, Platelet-rich plasma (PRP) is a concentrate of autologous platelets,has been used to effectively accelerate burn wound healing Platelet indices (PI), markers of platelet activation, are parameters obtained daily as a part of an automatic blood count, Platelet indices are related to platelets morphology and proliferation kinetics. Most commonly assessed platelet indices include the mean platelet volume (MPV), mean distribution width(PDW),Platelet larger cell ratio (PLCR) ,platelet crit (PCT), mean platelet mass (MPM),mean platelet component (MPC),Platelet component distribution width (PCDW) and immature platelet fraction (IPF).

The ratio of red blood cell distribution width (RWD) and platelet (PLT) (RPR) is considered an inflammation biomarker associated with the poor prognosis of number of diseases. There is two studies about PRP related to prognosis of major burn injury . results indicate that RPR-as an inflammatory index- can be used as a biomarker for prognosis of adult patients with major burn injuries.

Blood-based platelet parameters, due to their fairly easy accessibility and inexpensive methods of measurement, seem to be on the rise as potential novel biomarkers of numerous ,both acute and chronic disease. However, To date ,there are no data on the significance of platelets indices in evaluation with different degrees of burn .In this study we will evaluate the significance of platelet ratios and indices in different degrees of burn.