Effect of Platelet Rich Plasma and Keratinocyte Suspensions on Wound Healing
NCT ID: NCT00856934
Last Updated: 2009-03-06
Study Results
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View full resultsBasic Information
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COMPLETED
PHASE1
45 participants
INTERVENTIONAL
2005-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Control
Wounds covered with standard dressings: three layers of paraffin gauze, standard bandages, elastic bandage.
Standard dressings
Three layers of paraffin gauze, topped with standard dry bandages and an elastic bandage.
PRP
PRP sprayed onto the wound bed with Calcium Choride. Wounds covered with same standard dressings used in control group.
Autologous Platelet Rich Plasma
Platelet Rich Plasma isolated from patient blood sprayed onto wound bed along with 10% Calcium Chloride solution in a 10 to 1 proportion.
Standard dressings
Three layers of paraffin gauze, topped with standard dry bandages and an elastic bandage.
PRP+K
Keratinocytes suspended in PRP sprayed onto the wound bed with Calcium Choride. Wounds covered with same standard dressings used in control group.
Autologous Platelet Rich Plasma
Platelet Rich Plasma isolated from patient blood sprayed onto wound bed along with 10% Calcium Chloride solution in a 10 to 1 proportion.
Keratinocyte suspension
Autologous keratinocytes isolated from skin biopsy suspended in platelet rich plasma before spraying.
Standard dressings
Three layers of paraffin gauze, topped with standard dry bandages and an elastic bandage.
Interventions
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Autologous Platelet Rich Plasma
Platelet Rich Plasma isolated from patient blood sprayed onto wound bed along with 10% Calcium Chloride solution in a 10 to 1 proportion.
Keratinocyte suspension
Autologous keratinocytes isolated from skin biopsy suspended in platelet rich plasma before spraying.
Standard dressings
Three layers of paraffin gauze, topped with standard dry bandages and an elastic bandage.
Eligibility Criteria
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Inclusion Criteria
* Skin graft donor site size: 0.2mm deep, 30 to 40 cm2 surface area
Exclusion Criteria
* Patients treated with corticoids
* Patients suffering from terminal renal insufficiency
* Patients suffering from severe peripheral arteriopathy
18 Years
80 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire Vaudois
OTHER
Responsible Party
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Service de Chirurgie Plastique et Reconstructrice, CHUV
Principal Investigators
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Wassim Raffoul, PD, MER
Role: PRINCIPAL_INVESTIGATOR
CHUV - CPR
Locations
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Centre hospitalier Universitaire Vaudois
Lausanne, Canton of Vaud, Switzerland
Countries
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References
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Other Identifiers
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132/03
Identifier Type: -
Identifier Source: org_study_id
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