Study Results
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Basic Information
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SUSPENDED
30 participants
OBSERVATIONAL
2010-10-31
Brief Summary
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INTRODUCTION: Infection is cause of increased morbidity and mortality in burn patients, and its control is a major challenge also for skin graft integration. Wound and soft tissue infection rates are higher than microbiological diagnosis rates.
PURPOSE: To evaluate partial skin graft integration in relation to microbiological analysis of wounds in burn patients.
METHODS: This project will be a transversal, prospective, analytical, controlled study in humans, conducted in a single center, at Burn Care Unit of Department of Plastic Surgery at Federal University of São Paulo from October, 2010 to October, 2011. Data will be collected to characterize demographic and clinical aspects. Data analysis will be performed using Student's t-test and Friedman analysis of variance.
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Detailed Description
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INTRODUCTION: Early excision and partial skin graft is state-of-the-art in burns treatment. Otherwise, infection is cause of increased morbidity and mortality in burn patients, and its control is a major challenge also for skin graft integration. Wound and soft tissue infection rates are higher than microbiological diagnosis rates. This difference is related to moderate sensibility of cultures in general. Precise bacterial diagnostic and its susceptibility to specific antibiotics are prerequisite for adequate treatment of burn patients and skin graft integration.
PURPOSE: To evaluate partial skin graft integration in relation to microbiological analysis of wounds in burn patients.
METHODS: This project was approved at Ethics Committee at Federal University of São Paulo (1272/10). It will be a transversal, prospective, analytical, controlled study in humans, conducted in a single center, at Burn Care Unit of Department of Plastic Surgery at Federal University of São Paulo from October, 2010 to October, 2011. Thirty patients will be included in this study after reading and signing a consent form. Data will be collected using an evaluation sheet to characterize demographic and clinical aspects, including partial skin graft integration, use of topical and systemic antibiotics and infection rates in all sites (blood, urine, skin, tracheal aspirate and bronchial lavage). Data analysis will be performed using Student's t-test and Friedman analysis of variance.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* More than 18 years of age
* Burned patient
* Inpatient of Burn Center of Federal University of São Paulo
* Upper 5% of TBSA
* Debridement and skin graft indication and procedure realization
Exclusion Criteria
* Not have debridement or graft indication
* Under 5% of TBSA
* Skin disease
* Clinical disease that contraindication procedure
* Clinical disease that directly interferes with infectious process and wound healing
18 Years
ALL
No
Sponsors
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Federal University of São Paulo
OTHER
Responsible Party
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ALFREDO GRAGNANI FILHO
Associated Professor
Principal Investigators
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ALFREDO GRAGNANI, MD PhD
Role: PRINCIPAL_INVESTIGATOR
UFSaoPaulo
LYDIA M FERREIRA, MD Full Prof
Role: STUDY_CHAIR
UFSaoPaulo
Other Identifiers
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Graft take in burns
Identifier Type: -
Identifier Source: org_study_id
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