Characteristics of Hoffa Adipose Tissue and Intramuscular Adipose Tissue in the Quadriceps Muscle
NCT ID: NCT05955976
Last Updated: 2023-07-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
20 participants
OBSERVATIONAL
2023-07-20
2024-03-20
Brief Summary
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Crosstalk between skeletal muscle and structures around and in the joint is of interest. In physical deconditioning and aging, it has been reported that skeletal muscle can be replaced by adipose tissue. Several factors involved in the development of OA but also of adipose tissue may be involved in these muscular changes. Of interest, in patients with KOA, quadriceps weakness is an ubiquitous clinical finding. Infiltration of adipose tissue in skeletal muscle has been shown to affect muscle strength and mobility and be linked to cartilage volume loss and the occurrence/progression of KOA.
The main objective of this study is to compare the characteristics of the Hoffa tissus and the intamuscular fat (IMF) tissus in the quadriceps muscle in patients with gonarthrosis requiring total knee prosthesis.
This is a single-centre study based on a collection of surgical waste and is categorized as Research Not Involving Human subjects.
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Patients suffering of knee ostheoarthritis undergoing a surgery for a total knee prosthesis.
BIOPSY
biopsy
Interventions
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BIOPSY
biopsy
Eligibility Criteria
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Inclusion Criteria
* Patient having a confirmed diagnosis of knee ostheoarthritis
* Patient undergoing a surgery for a total knee prosthesis for knee ostheoarthritis
Exclusion Criteria
40 Years
85 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de Nice
OTHER
Responsible Party
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Locations
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Nice University Hospital
Nice, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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23Rhumato02
Identifier Type: -
Identifier Source: org_study_id
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