Multimodal Imaging of Subchondral Bone in Knee Osteoarthritis : Predictive Model

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

167 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-11-29

Study Completion Date

2023-06-19

Brief Summary

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Predictive factors of osteoarthritis progression are not yet well understood. However, a growing role attaches importance to the subchondral bone. The aim of the present project is to determine predictive factors of progression of osteoarthritis at the knee by a multimodal characterization of subchondral bone by Medical Resonnance Imaging, direct high resolution digitization radiographs and bone texture analysis. At the end of the project, an innovative imaging device, combining semi-automatic softwares for texture analysis, control detection and image registration would be supplied. This will enable on the one hand a more accurate and reproducible way to measure the joint space width of the affected compartment and on the other hand, an assistance to better detect patients at risk of progression of their knee osteoarthritis. Identifying These "progressors" patients might permit their selection in clinical trials at baseline adapted to their severe disease, using for example biologic treatments targeting knee osteoarthritis. The main objective of this study is to analyze the predictive capacities of bone texture parameters measured on the high-resolution radiography of the knee on the structural evolution of the knee osteoarthritis at 3 years.

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Detailed Description

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Conditions

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Knee Osteoarthritis Joint Disease Arthritis Musculoskeletal Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Interventional study among patients suffering from knee osteoarthritis for at least six months. All the patients will benefit from a multimodal imaging and clinical assessment.

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Imaging

multimodal imaging and clinical assessment

Group Type OTHER

multimodal imaging

Intervention Type DIAGNOSTIC_TEST

Interventions

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multimodal imaging

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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clinical assessment

Eligibility Criteria

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Inclusion Criteria

* knee osteoarthritis according to the criteria of knee osteoarthritis of American College of Rheumatology.
* Having felt a painful push in the last 6 months.
* Visual Analogic Scale pain \> 4 on a 0 to 10 scale.
* having a Radiographic score of OARSI (Osteoarthritis Research Society International Score) from 2 to 3 whether it is for the presence of a joint space narrowing or the presence of an osteophyte

Exclusion Criteria

* Patello-femoral degenerative osteoarthritis isolated.
* Incapacitated to consider the position in schuss for the realization of the radiography.
* Valgus \> in 5 °
* Secondary degenerative osteoarthritis

Minimum Eligible Age

45 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No