Weight-Bearing Magnetic Resonance Imaging (MRI) for Analysis of Knee Osteoarthritis (OA)
NCT ID: NCT00665548
Last Updated: 2009-04-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
33 participants
OBSERVATIONAL
2008-03-31
2009-02-28
Brief Summary
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1. whether the different x-ray and MRI techniques will give the same or different information about the knee joint and
2. which part of the knee joint will show the biggest change using the different x-ray and MRI techniques. The study is not designed to test a hypothesis.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Normal Subjects
Female subjects scoring Kellgren \& Lawrence grade 0.
X-ray; magnetic resonance imaging
Knee x-rays: acquired in both a standard or weight-bearing position and in non-weight-bearing position to measure joint space width and look at signs of osteoarthritis.
3 Tesla MRI: magnetic resonance imaging of the study knee during weight-bearing conditions and traditional non-loaded condition all acquired with the same sequences.
OA Subjects
Female subjects with Kellgren \& Lawrence score of 2 or 3.
X-ray; magnetic resonance imaging
Knee x-rays: acquired in both a standard or weight-bearing position and in non-weight-bearing position to measure joint space width and look at signs of osteoarthritis.
3 Tesla MRI: magnetic resonance imaging of the study knee during weight-bearing conditions and traditional non-loaded condition all acquired with the same sequences.
Interventions
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X-ray; magnetic resonance imaging
Knee x-rays: acquired in both a standard or weight-bearing position and in non-weight-bearing position to measure joint space width and look at signs of osteoarthritis.
3 Tesla MRI: magnetic resonance imaging of the study knee during weight-bearing conditions and traditional non-loaded condition all acquired with the same sequences.
Eligibility Criteria
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Inclusion Criteria
* 40 years and older
* Subjects who are willing and able to comply with x-ray and MRI procedures
* Evidence of a personally signed and dated consent document
Additional inclusion for normal controls:
* Infrequent knee pain, aching, or stiffness during the past year or infrequent use of medication for treatment of knee pain during the past year
* No evidence of OA on either knee (i.e. K-L grade = 0 diagnosed by knee radiography)
Additional inclusion for OA patients:
* Pain, aching, or stiffness on most days of a month during the past year; or use of medication for treatment of knee pain on most days of a month during the past year
* Kellgren-Lawrence Grade 2 or 3 of the study knee obtained on a Standard knee radiograph (with either the same or less severe OA, or no OA in the contralateral knee)
Exclusion Criteria
* Women at risk of pregnancy
* Weight greater than 250 lbs
* History of surgery in the study knee
* History of other diseases involving the study knee joint including inflammatory joint diseases, crystalline disease, and infection of the study knee
40 Years
FEMALE
Yes
Sponsors
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Pfizer
INDUSTRY
University of California, San Francisco
OTHER
Responsible Party
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UCalifroniaSF
Principal Investigators
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Sharmila Majumdar, PhD
Role: PRINCIPAL_INVESTIGATOR
University of California, San Francisco
Thomas Link, MD
Role: PRINCIPAL_INVESTIGATOR
University of California, San Francisco
Locations
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University of California - San Francisco
San Francisco, California, United States
Countries
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Other Identifiers
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Pfizer West
Identifier Type: -
Identifier Source: org_study_id
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